日韩在线观看网站-日韩在线观看视频网站-日韩在线观看视频免费-日韩在线观看视频黄-日韩在线观看免费完整版视频-日韩在线观看免费

科學研究：

研究方向：

主要進行心血管藥理學、膜通道藥理學、藥物發現與開發等相關研究。

承擔科研項目情況：

先后主持了美國NIH，PKD和AHA及中國國家自然科學基金、985專項基金（歸國人員科研啟動基金）等多個研究項目。

目前項目：

1. “重大新藥創制”科技重大專項基金子課題：銀杏內酯B治療多囊腎病的藥效學研究。

2. 國家自然科學基金：尿素通道蛋白在尿濃縮過程中的作用機制。

3. 國家自然科學基金：水通道蛋白在多囊腎病腎囊泡發生和發展過程中的作用。

4. 高等學校博士學科點專項科研基金：天然單體化合物G315治療多囊腎病的藥理學研究。

5. 985專項基金（歸國人員科研啟動基金）：膜通道藥理學。

科研成果：

(1) 首次發現尿素通道蛋白UT-B 可轉運水；

(2) 建立了尿素通道蛋白家族第一個基因敲除小鼠模型；

(3) 發現上皮細胞膜表面矩陣排列蛋白為水通道蛋白AQP4，揭開了一個25年的形態學之謎；

(4) 首次克隆了人水通道蛋白4的cDNA和并鑒定了其基因結構和蛋白特性；

(5) 以基因敲入手段模擬出人遺傳性腎性尿崩癥第一個小鼠模型；

(6) 成功地建立了水通道1，2，3，4，8的基因敲除小鼠模型；

(7) 首次應用表達水通道蛋白AQP1的重組非復制型腺病毒對的尿崩癥小鼠模型進行基因治療；

(8) 獲得了水通道蛋白和尿素通道蛋白在尿濃縮機制中作用的系統性生理學數據；

(9) 發現新的 CFTR突變體改正劑小分子化合物；

(10) 證實CFTR在多囊腎發病過程中起重要作用，提示CFTR抑制劑有可能用于治療多囊腎；

(11) 發現銀杏內酯B可抑制多囊腎囊泡的生成和增大，目前正在進行體內藥效學評價；

(12) 利用高通量篩選獲得小分子尿素通道抑制劑，并已發現該化合物在體內具有利尿作用。

論文專著：

發表英文論文：

1. Lei T., L. Zhou, A.T. Layton, H. Zhou, X. Zhao, L. Bankir, and B. Yang*. (2011) Role of thin descending limb urea transport in renal urea handling and the urine concentrating mechanism. Am J Physiol Renal Physiol 2011 Aug 17. [Epub ahead of print]

2. Li X., J. Ran, H. Zhou, T. Lei, L. Zhou, J. Han, and B. Yang*. (2011) Mice Lacking Urea Transporter UT-B Display Depression-Like Behavior. J Mol Neurosci. 2011 Jul 13. [Epub ahead of print]

3. Phuan P.W., B. Yang, J. Knapp, A. Wood, G.L. Lukacs, M.J. Kurth, A.S. Verkman. (2011) Cyanoquinolines with Independent Corrector and Potentiator Activities Restore {triangleup}F508-CFTR Chloride Channel Function in Cystic Fibrosis. Mol Pharmacol. 2011 Jul 5. [Epub ahead of print]

4. Liu L., T. Lei, L. Bankir, D. Zhao, X.Gai, X. Zhao, and B. Yang*.（2011）Erythrocyte permeability to urea and water: comparative study in rodents, ruminants, carnivores, humans, and birds. J Comp Physiol B. J Comp Physiol B. 181：65-72.

5. Lin G., L. Zhao, F. Yin, R. Lan, L. Li, X. Zhang, H. Zhang, and B. Yang*. (2011) TCF3 inhibits F9 embryonal carcinoma growth by the down-regulation of Oct4. Oncol Rep 26: 893-899.

6. Gao J., H. Zhou, T. Lei, L. Zhou, W. Li, X. Li, B. Yang*. （2011） Curcumin inhibits renal cyst formation and enlargement in vitro by regulating intracellular signaling pathways. European Journal of Pharmacology 654：92-99.

7. Liang Z., B. Guo, Y. Li , X. Li , X. Li, L. Zhao, L. Gao, X. Zhao, L. Zhang, B. Yang*. （2011）Plasmid-Based Stat3 siRNA delivered by Hydroxyapatite Nanoparticles Suppresses Prostate Tumor Growth in vivo. Asia J Androl 13:481-486.

8. Yu G., B. Yang, A. S. Verkman, M. J. Kurth.（2010）Isoxazolopyrimidines as Novel DF508-CFTR Correctors. SYNLETT 7：1063–1066

9. Mills A.D., C. Yoo, J.D. Butler, B. Yang, A.S. Verkman, ang M.J. Kurth. (2010) Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorg Med Chem Lett 20:87-91.

10. Meng Y., C. Zhao, X. Zhang, H. Zhao, L. Guo, B. Lü, X. Zhao X, and B. Yang. (2009) Surface electrocardiogram and action potential in mice lacking urea transporter UT-B. Sci China C Life Sci 52:474-478.

11. Yu H., Y. Meng, L. Wang, X. Jin, L. Gao, L. Zhou, K. Ji, Y. Li, L. Zhao, G. Chen, X. Zhao, and B. Yang*. (2009) Differential Protein Expression in Heart in UT-B Null Mice with Cardiac Conduction Defects. Proteomics 9:504-511

12. Yang B., D. Zhao, and A.S. Verkman. (2009) Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation. FASEB J. 23:503-512.

13. Yu G.J., C.L.Yoo, B. Yang, M.W. Lodewyk, L. Meng, T.T. El-Idreesy, J.C. Fettinger, D.J. Tantillo, A.S. Verkman, and M.J. Kurth. (2008) Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. J Med Chem 51:6044-6054.

14. Yoo C.L., G.J. Yu, B. Yang, L.I. Robins, A.S. Verkman, and M.J. Kurth. (2008) 4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. Bioorg Med Chem Lett 18:2610-2614.

15. Yang B.*, N.D. Sonawane, D. Zhao, S. Somlo, and A.S. Verkman. (2008) Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. J Am Soc Nephrol 19:1300-1310.

16. Yang B., Z. Zador, and A.S. Verkman. (2008) Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. J Biol Chem 283:15280-15286.

17. Yang B., H. Zhang, and A.S. Verkman. (2008) Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides. Bioorg Med Chem 16:7489-7493.

18. Beall M.H., S. Wang, B. Yang, N. Chaudhri, F. Amidi, and M.G. Ross. (2007) Placental and membrane aquaporin water channels: correlation with amniotic fluid volume and composition. Placenta 28:421-428.

19. Zhao D., N.D. Sonawane, M.H. Levin, and B. Yang*.（2007）Comparative transport efficiencies of urea analogues through urea transporter UT-B. Biochim Biophys Acta 1768: 1815-1821.

20. Guo L., D. Zhao, Y. Song, Y. Meng, H. Zhao, X. Zhao, and B. Yang*. （2007）Reduced urea flux across the blood-testis barrier and early maturation in the male reproductive system in UT-B-null mice. Am J Physiol Cell Physiol 293: C305-C312.

21. Jin S., Y. Liu, L. Xu, Y. Jiang, Y. Wang, B. Yang, H. Yang, and T. Ma. (2006) Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system. World J Gastroenterol 12:1092-1097.

22. Pan Y.Z., X.Y. Xiao, D. Zhao, L. Zhang, G.Y. Ji, Y. Li, B. Yang, D.C. He, and X.J. Zhao. (2006) Application of surface-enhanced laser desorption/ionization time-of-flight-based serum proteomic array technique for the early diagnosis of prostate cancer. Asian J Androl 8:45-51.

23. Suen Y.F., L. Robins, B. Yang, A.S. Verkman, M.H. Nantz, and M.J. Kurth. (2006) Sulfamoyl-4-oxoquinoline-3-carboxamides: novel potentiators of defective DeltaF508-cystic fibrosis transmembrane conductance regulator chloride channel gating. Bioorg Med Chem Lett 16:537-540.

24. Yang B.*, D. Zhao, L. Qian, and A.S. Verkman. (2006) Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deleltion. Am J Physiol Renal Physiol 291:F465-F472.

25. Zhao D., L. Bankir, L. Qian, D. Yang, and B. Yang*. (2006) Urea and urine concentrating ability in mice lacking AQP1 and AQP3. Am J Physiol Renal Physiol 291:F429-F438.

26. Butler T.L., C.G. Au, B. Yang, J.R. Egan, Y.M. Tan, E.C. Hardeman, K.N. North, A.S. Verkman, and D.S. Winlaw. (2006) Cardiac Aquaporin Expression in Human, Rat and Mouse. Am J Physiol Heart Circ Physiol 291:H705-H713.

27. Yang B.*, D. Zhao, S. Eugene, and A.S. Verkman. (2006) Evidence from knockout mice against physiologically significant aquaporin-8 facilitated ammonia transport. Am J Physiol cell Physiol 291:C417-C423.

28. Li Z., D. Zhao, B. Gong, Y. Xu, H. Sun, B. Yang, and X. Zhao. (2006) Decreased saliva secretion and down-regulation of AQP-5 in submandibular gland in irradiated rats. Radiat Res 165: 678-687.

29. Yang B., D. Zhao, and A.S. Verkman. (2006) Evidence against functionally significant aquaporin expression in mitochondria. J Biol Chem. 281:16202-16206.

30. Levin M.H,, S. Sullivan, D. Nielson, B. Yang, W.E. Finkbeiner, and A.S. Verkman. (2006) Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins. J Biol Chem 281:25803-25812.

31. Yang B.*, J.K. Kim, and A.S. Verkman. (2006) Comparative efficacy of HgCl(2) with candidate aquaporin-1 inhibitors DMSO, gold, TEA(+) and acetazolamide. FEBS Lett 580:6679-6684.

32. Meng Y., X. Zhou, Y. Li, D. Zhao, S. Liang, X. Zhao, and B. Yang* . (2005) A novel mutation at the JK locus causing Jk null phenotype in a Chinese family. Sci China C Life Sci 48:636-640.

33. Yang B., Y. Song , D. Zhao, and A.S. Verkman . (2005) Phenotype analysis of aquaporin-8 null mice. Am J Physiol cell Physiol 288:C1161-C1170.

34. Hara-Chikuma M, B. Yang, N.D. Sonawane, S. Sasaki, S. Uchida, and A.S. Verkman. (2005) ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation. J Biol Chem 280:1241-1247.

35. Klein J.D., J.M. Sands, L. Qian, X. Wang, and B. Yang*. (2004) Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B. J Am Soc Nephrol 15:1161-1167.

36. Bankir L., K. Chen, and B. Yang*. (2004) Lack of UT-B in vasa recta and red blood cells prevents urea-induced improvement of urinary concentrating ability. Am J Physiol Renal Physiol 286:F144-F151.

37. Oshio K., D.K. Binder, B. Yang, S. Schecter, A.S. Verkman, and G.T. Manley. (2004) Expression of aquaporin water channels in mouse spinal cord. Neuroscience 127:685-693.

38. Yang B., L. Bankir, A. Gillepsie, C. J. Epstein, and A. S. Verkman. (2002) Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J BIol Chem 277:10633-10637.

39. Fang X., B. Yang, M. A. Matthay and A.S. Verkman. (2002) Evidence against aquaporin-1 dependent CO2 permeability in lung and kidney. J Physiol 542:63-69.

40. Yang B., and A. S. Verkman. (2002) Analysis of double knokout mice lacking aquaporin-1 and urea transporter UT-B: Evidence for UT-B facilitated water transport in erythrocytes. J Biol Chem 277:36782-36786.

41. Mann S.E., E. A. Ricke, B. Yang, A. S. Verkman, and R. N. Taylor. (2002) Expression and localization of aquaporin 1 and 3 in human fetal membranes. Am. J Obstet Gynecol 187:902-907.

42. Yang B., T. Ma, and A. S. Verkman. (2001) Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J Biol Chem 276:624-628.

43. Yang B., A. Gillespie, E. J. Carlson, C. J. Epstein, and A. S. Verkman. (2001) Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem 276:2775-2779.

44. Song Y., S. Jayaraman, B. Yang, M. A. Matthay, and A. S. Verkman. (2001) Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. J Gen Physiol 117:573-582.

45. Ma T., S. Jayaraman, K. S. Wang, Y. Song, B. Yang, J. Li, J. A. Bastidas, and A. S. Verkman. (2001) Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am J Physiol Cell Physiol 280:C126-C134.

46. Yang B., J. M. Verbavatz, Y. Song, L. Vetrivel, G. Manley, W. M. Kao, T. Ma, and A. S. Verkman. (2000) Skeletal muscle function and water permeability in aquaporin-4 deficient mice. Am J Physiol Cell Physiol 278:C1108-C1115.

47. Yang B., T. Ma, J. Y. Dong, and A. S. Verkman. (2000) Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Hum Gene Ther 11:567-575.

48. Yang B., N. Fukuda, A. van Hoek, M. A. Matthay, T. Ma, and A. S. Verkman. (2000) Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J Biol Chem 275:2686-2692.

49. van Hoek A. N., T. Ma, B. Yang, A. S. Verkman, and D. Brown. (2000) Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. Am J Physiol Renal Physiol 278:F310-F316.

50. Song Y., B. Yang, M. A. Matthay, T. Ma, and A. S. Verkman. (2000) Role of aquaporin water channels in pleural fluid dynamics. Am J Physiol Cell Physiol 279:C1744-C1750.

51. Moore M., T. Ma, B. Yang, and A. S. Verkman. (2000) Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res 70:557-562.

52. Ma T., Y. Song, B. Yang, A. Gillespie, E. J. Carlson, C. J. Epstein, and A. S. Verkman. (2000) Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A 97:4386-4391.

53. Foster W., A. Helm, I. Turnbull, H. Gulati, B. Yang, A. S. Verkman, and W. R. Skach. (2000) Identification of sequence determinants that direct different intracellular folding pathways for aquaporin-1 and aquaporin-4. J Biol Chem 275:34157-34165.

54. Yang B., T. Ma, Z. Xu, and A. S. Verkman. (1999) cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus. Genomics 57:79-83.

55. Yang B., H. G. Folkesson, J. Yang, M. A. Matthay, T. Ma, and A. S. Verkman. (1999) Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Am J Physiol 276:C76-C81.

56. Tamarappoo B. K., B. Yang, and A. S. Verkman. (1999) Misfolding of mutant aquaporin-2 water channels in nephrogenic diabetes insipidus. J Biol Chem 274:34825-34831.

57. Chou C. L., M. A. Knepper, A. N. Hoek, D. Brown, B. Yang, T. Ma, and A. S. Verkman. (1999) Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Invest 103:491-496.

58. van Hoek A. N., B. Yang, S. Kirmiz, and D. Brown. (1998) Freeze-fracture analysis of plasma membranes of CHO cells stably expressing aquaporins 1-5. J Membr Biol 165:243-254.

59. Yang B., and A. S. Verkman. (1998) Urea transporter UT3 functions as an efficient water channel. Direct evidence for a common water/urea pathway. J Biol Chem 273:9369-9372.

60. Ma T., B. Yang, M. A. Matthay, and A. S. Verkman. (1998) Evidence against a role of mouse, rat, and two cloned human T1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Am J Respir Cell Mol Biol 19:143-149.

61. Ma T., B. Yang, A. Gillespie, E. J. Carlson, C. J. Epstein, and A. S. Verkman. (1998) Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem 273:4296-4299.

62. Chou C. L., T. Ma, B. Yang, M. A. Knepper, and A. S. Verkman. (1998) Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice. Am J Physiol 274:C549-C554.

63. Yang B., and A. S. Verkman. (1997) Water and glycerol permeabilities of aquaporins 1-5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes. J Biol Chem 272:16140-16146.

64. Yang B., A. N. van Hoek, and A. S. Verkman. (1997) Very high single channel water permeability of aquaporin-4 in baculovirus-infected insect cells and liposomes reconstituted with purified aquaporin-4. Biochemistry 36:7625-7632.

65. Verkman A. S., and B. Yang. (1997) Aquaporins and ion conductance. Science 275:1491; discussion 1492.

66. Ma T., B. Yang, and A. S. Verkman. (1997) Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart. Biochem Biophys Res Commun 240:324-328.

67. Ma T., B. Yang, F. Umenishi, and A. S. Verkman. (1997) Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. Genomics 43:387-389.

68. Ma T., B. Yang, A. Gillespie, E. J. Carlson, C. J. Epstein, and A. S. Verkman. (1997) Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest 100:957-962.

69. Yang B., D. Brown, and A. S. Verkman. (1996) The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells. J Biol Chem 271:4577-4580.

70. Umenishi F., E. P. Carter, B. Yang, B. Oliver, M. A. Matthay, and A. S. Verkman. (1996) Sharp increase in rat lung water channel expression in the perinatal period. Am J Respir Cell Mol Biol 15:673-679.

71. Ma T., B. Yang, and A. S. Verkman. (1996) cDNA cloning of a functional water channel from toad urinary bladder epithelium. Am J Physiol 271:C1699-C1704.

72. Ma T., B. Yang, and A. S. Verkman. (1996) Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel. Genomics 33:382-388.

73. Ma T., B. Yang, W. L. Kuo, and A. S. Verkman. (1996) cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13. Genomics 35:543-550.

74. Yang B., T. Ma, and A. S. Verkman. (1995) cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units. J Biol Chem 270:22907-22913.

75. Yang B., X. Su, Y. Zhu, K. Sun, D. Xu, Z. Lu, and Y. Jin. (1991) Inhibition of methyl methanesulfonate-induced unscheduled DNA synthesis in spermatozoa of mice by Poly I-C. Acta Pharmacologica Sinica 12(6):497-499.

Review Articles

76. Sun Y., H. Zhou, and B. Yang* (2011) Drug discovery for polycystic kidney disease (invited review). Acta Pharmacologica Sinica 32:805-811.

77. Zhang L., B. Yang, H. Zhang, J. Wang, H. Wang, and X. Zhao (2011) Prostate cancer: an emerging threat to the health of aging men in Asia (invited review). Asian Journal of Andrology 13: 574-578.

78. Yang B.*, and L. Bankir (2005) Urea and urine concentrating ability: New insights from studies on mice (invited review). Am J Physiol Renal Physiol 288:F881-F896.

79. Verkman A.S., K. Oshio, B. Yang, Y. Song, T. Ma, D.K. Binder, M. Papadopoulos, E.I. Solenov, G.T. Manley. (2003) Role of aquaporin water channels in central nervous system revealed by phenotype of aquaporin null mice. J of Neurochemistry 87: 30-40 Suppl.

80. Verkman A.S., and B. Yang. (2002) Aquaporin gene delivery to kidney. Kidney Int 61 Suppl 1:120-124

81. Verkman A.S., J. Li, D. Zhang, B. Yang, T. Ma, G. T. Manley, and Y. Song . (2001) Phenotype analysis of aquaporin transgenic mice. Bull Mol Med 7-8:3-16.

82. Verkman A.S., J. Li, T. Ma, and B. Yang. (2001) Role of aquaporin water channels in kidney function studied using transgenic mice. Clin Exp Nephrol 5:75-84.

83. Yang B*. (2000) The human aquaporin gene family. Current Genomics 1: 91-102.

84. Verkman A.S., B. Yang, Y. Song, G. T. Manley, and T. Ma. (2000) Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp Physiol 85:233S-241S.

Books and Chapters

85. A.S. Verkman, B. Yang, W. R. Skach, Y. Song, G.T. Manley and T. Ma. Genetic and biophysical approaches to study water channel biology. In: Current Topics in Membranes, Volume 51. Academic Press. p. 185-233, 2001

86. A.S. Verkman, B. Yang, L.B. Shi, A.N. van Hoek, J. Farinas, A. Frigeri, M. Gropper, M.A. Matthay, B. Tamarappoo, F. Umenishi, and T. Ma. Water channel structure and function. In: Neurohypophysis. T. Saito, K. Kurokawa and S. Yoshida, eds. Elsevier Science, Amsterdam, p. 455-466, 1996

發表中文論文：

1. 李飛，楊寶學*。天然產物與藥物發現評述。國際中醫中藥雜志。2011，33（7）：612-615。

2. 李欣，周虹，楊寶學*。一氧化氮與抑郁癥發生相關性的研究進展。國際神經病學神經外科學雜志。2011，37：352-356。

3. 陳燕，郭寶鋒，邵晨，楊寶學，趙雪儉。多囊腎小鼠腎功能的改變。中國實驗診斷學 2011-01-25。

4. 周澧，周虹，楊寶學*。常染色體顯性遺傳多囊腎病發病相關信號轉導通路的研究進展。中國病理生理雜志。2010 ，26（5）：1020-10-24。

5. 闞秀芳，周虹，楊寶學*。水通道蛋白在多囊腎病小鼠腎囊泡上皮細胞的表達與調控。中華腎臟病雜志。2010，26（1）：39-42。

6. 高晉生，楊寶學*。常染色體顯性遺傳多囊腎病的治療研究進展。中國藥理學通報 2009，25：141-144。

7. 趙丹，朱建國，王偉華，楊寶學，趙雪儉。水通道蛋白3在人前列腺組織中的表達及意義。中國病理生理雜志 2009-10-15