發(fā)明專(zhuān)利：
發(fā)明公開(kāi)：
[1]宋永相,楊佳凡,周鎮(zhèn)檳,李曉悅,馬俊英,閆巖,鞠建華. 一類(lèi)異腈基化合物及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N115894307A,2023-04-04.
[2]鞠建華,蔡存磊,陳盈盈,孫長(zhǎng)利,馬俊英. 兩個(gè)二苯醚化合物及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東省：CN115710167A,2023-02-24.
[3]馬俊英,喬伊君,鞠建華,楊佳凡,宋永相. 一株海洋鏈霉菌及其環(huán)八肽化合物在制備抗耐藥菌藥物中的應(yīng)用[P]. 廣東�。篊N115124597A,2022-09-30.
[4]安法梁,鄭高帆,朱云飛,鞠建華,馬俊英. 深海鏈霉菌基因工程突變株生產(chǎn)怡萊霉素E的高產(chǎn)培養(yǎng)基及其規(guī)�；l(fā)酵工藝[P]. 上海市：CN114540446A,2022-05-27.
[5]鞠建華,周鎮(zhèn)檳,楊佳凡,宋永相,田新朋. 兩個(gè)大環(huán)內(nèi)酯化合物及其在制備抗菌、抗癌藥物中的應(yīng)用[P]. 廣東�。篊N114437155A,2022-05-06.
[6]鞠建華,宋永相,楊佳凡. 一類(lèi)骨架新穎的6/6/6/6/5/5環(huán)生物堿類(lèi)化合物及其在制備抗菌藥物中的應(yīng)用[P]. 廣東省：CN114349762A,2022-04-15.
[7]宋永相,鞠建華,劉田,李潔,楊佳凡,李曉悅,盧瓊,楊青. 深海放線菌11791在制備防治農(nóng)牧業(yè)鱗翅目害蟲(chóng)藥物中的應(yīng)用[P]. 廣東�。篊N114009451A,2022-02-08.
[8]李青連,鞠建華,梁智鋮,李駿,凌春耀. 4’-N-demethyl-vicenistatin及其制備方法和應(yīng)用[P]. 廣東�。篊N113912658A,2022-01-11.
[9]楊青,劉田,宋永相,盧瓊,鞠建華. 雙吲哚吡咯類(lèi)化合物的應(yīng)用[P]. 廣東�。篊N113207883A,2021-08-06.
[10]李青連,許潤(rùn),宋永相,李駿,鞠建華. 一種環(huán)六肽化合物desotamide A4及其在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N113150077A,2021-07-23.
[11]馬俊英,朱湘成,段燕文,鞠建華. 一種化合物ilamycin E-1/E-2的微生物發(fā)酵制備方法[P]. 廣東省：CN113122599A,2021-07-16.
[12]鞠建華,邵明偉,孫長(zhǎng)利,李青連,王曉雪. 一種海洋真菌-細(xì)菌共生體及其代謝產(chǎn)物和在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N112694983A,2021-04-23.
[13]安法梁,鄭高帆,朱云飛,鞠建華,馬俊英. 利用深海鏈霉菌生產(chǎn)怡萊霉素E的培養(yǎng)基及其制備方法[P]. 上海市：CN112608965A,2021-04-06.
[14]鞠建華,李駿,劉志永,馬俊英,張?zhí)煊? 一種怡萊霉素F衍生物及其在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東�。篊N111647050A,2020-09-11.
[15]鞠建華,張?zhí)煊?孫長(zhǎng)利,劉志永,馬俊英. 海洋環(huán)肽化合物及其在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東�。篊N111303247A,2020-06-19.
[16]鞠建華,陳姜,桂春,李青連,田新朋. 一種定向生產(chǎn)抗病毒和抗菌活性化合物的基因工程菌株及其應(yīng)用[P]. 廣東省：CN111269867A,2020-06-12.
[17]宋永相,楊佳凡,賴添財(cái),鞠建華. 深海放線菌生物制劑在制備預(yù)防柑橘潰瘍疾病藥物中的應(yīng)用[P]. 廣東省：CN111096337A,2020-05-05.
[18]鞠建華,劉夢(mèng)嬋,孫長(zhǎng)利,馬俊英,李青連. 一類(lèi)雙脫甲基放線菌素衍生物及其在制備抗耐藥菌感染藥物中的應(yīng)用[P]. 廣東�。篊N110669103A,2020-01-10.
[19]馬俊英,鞠建華,黃洪波,張春燕,賈艷璽,李巖. 化合物ilamycin F及其應(yīng)用[P]. 廣東�。篊N110218244A,2019-09-10.
[20]馬俊英,張華,解青,鞠建華. 化合物ilamycin C及其同系物在制備治療三陰乳腺癌藥物中的應(yīng)用[P]. 廣東�。篊N109985229A,2019-07-09.
[21]鞠建華,孫長(zhǎng)利,張善文,桂春,張華. 一類(lèi)安莎全碳環(huán)聚酮類(lèi)抗生素及其在制備抗菌藥物或抗腫瘤藥物中的應(yīng)用[P]. 廣東省：CN109810919A,2019-05-28.
[22]馬俊英,孫長(zhǎng)利,劉志勇,張?zhí)煊?鞠建華. 環(huán)肽類(lèi)抗生素及其制備方法和在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東省：CN109762046A,2019-05-17.
[23]鞠建華,張善文,桂春,邵明偉,黃洪波. 一種海洋鏈霉菌、衣霉素類(lèi)化合物及其制備方法[P]. 廣東：CN108660093A,2018-10-16.
[24]李青連,鞠建華,秦湘靜,劉靜. 一種高產(chǎn)環(huán)肽類(lèi)化合物的菌株[P]. 廣東：CN108587991A,2018-09-28.
[25]鞠建華,張善文,田新朋,桂春,秦湘靜,黃洪波. 一種海洋糖多孢菌及其在制備紅霉素衍生物中的應(yīng)用[P]. 廣東：CN108485991A,2018-09-04.
[26]李青連,鞠建華,秦湘靜,劉靜. 一種高產(chǎn)含有L-Val結(jié)構(gòu)單元的化合物的菌株△mfnH[P]. 廣東：CN108486028A,2018-09-04.
[27]鄧音樂(lè),鞠建華,蒙麗麗,孫長(zhǎng)利,趙朔,孫秀云,陳俐. 化合物Sorbicillin在防治白色念珠菌中的應(yīng)用[P]. 廣東：CN108338979A,2018-07-31.
[28]鄧音樂(lè),鞠建華,蒙麗麗,孫長(zhǎng)利,趙朔,孫秀云,陳俐. 一種防治白色念珠菌化合物及其制備方法與應(yīng)用[P]. 廣東：CN108191693A,2018-06-22.
[29]鞠建華,潘華奇,田新朋. 一種多功能暹羅芽孢桿菌及其生物活性物質(zhì)的制備和應(yīng)用[P]. 廣東：CN108060100A,2018-05-22.
[30]鞠建華,宋永相,李潔,黃洪波. 一類(lèi)角環(huán)素化合物及其在制備抗腫瘤或抗菌藥物中的應(yīng)用[P]. 廣東：CN106834160A,2017-06-13.
[31]鞠建華,宋永相,李青連,胡云峰. 一類(lèi)大環(huán)內(nèi)酯化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN106632221A,2017-05-10.
[32]鞠建華,馬俊英,黃洪波,張春燕,賈艷璽,李巖. 一種定向生產(chǎn)抗結(jié)核活性和抗腫瘤活性化合物的基因工程菌株及其應(yīng)用[P]. 廣東：CN106497827A,2017-03-15.
[33]鞠建華,馬俊英,黃洪波,賈艷璽,張春燕. 環(huán)肽類(lèi)化合物在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN106397544A,2017-02-15.
[34]鞠建華,張?zhí)煊?馬俊英,劉永志. 一種海洋鏈霉菌、及其環(huán)肽化合物在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東：CN106279370A,2017-01-04.
[35]鞠建華,桂春,李青連,程偉鴿. 一種海洋鏈霉菌及其在制備那西肽中的應(yīng)用[P]. 廣東：CN106119157A,2016-11-16.
[36]鞠建華,宋永相,謝運(yùn)昌,秦湘靜. 一種利用深海鏈霉菌SCSIO 5604制備抗生素dihydrotetrodecamycin的方法[P]. 廣東：CN105925637A,2016-09-07.
[37]李文均,劉晴,陳微,高銳,段焰青,侯偉,鞠建華. 一株擬無(wú)枝菌酸菌及利用該菌制備特戊依羅霉素的方法[P]. 廣東：CN105886421A,2016-08-24.
[38]鞠建華,宋永相,許芳. 一類(lèi)環(huán)六肽化合物及其在制備抗良性前列腺增生藥物中的應(yīng)用[P]. 廣東：CN105294842A,2016-02-03.
[39]鞠建華,李青連,秦湘靜,劉靜. 氨基轉(zhuǎn)移酶和異構(gòu)酶在催化形成L-allo-Ile中的應(yīng)用[P]. 廣東：CN105154487A,2015-12-16.
[40]鞠建華,朱清華,黃洪波,宋永相,馬俊英,李青連. 一類(lèi)核苷類(lèi)抗生素及其在制備抗菌藥物中的應(yīng)用[P]. 廣東：CN105061537A,2015-11-18.
[41]鞠建華,謝運(yùn)昌. 一種灰綠霉素與綠灰霉素高產(chǎn)菌株及其構(gòu)建方法[P]. 廣東：CN104962578A,2015-10-07.
[42]張永光,李文均,劉晴,宋永相,鞠建華,王宏飛,李麗,張?jiān)?郭建偉. 一種生產(chǎn)安薩菌素P-3及15-羥基衍生物的擬諾卡氏菌及其制備方法和應(yīng)用[P]. 新疆：CN104877929A,2015-09-02.
[43]鞠建華,宋永相,李潔,黃洪波. 一類(lèi)角環(huán)素化合物及其在制備抗腫瘤或抗菌藥物中的應(yīng)用[P]. 廣東：CN104744533A,2015-07-01.
[44]鞠建華,張幸,桂春. 一種海洋鏈霉菌及其應(yīng)用[P]. 廣東：CN104630116A,2015-05-20.
[45]張幸,羅明和,鞠建華. 一種吲哚-3-甲醛類(lèi)化合物的制備方法和應(yīng)用[P]. 廣東：CN104402792A,2015-03-11.
[46]鞠建華,馬俊英,張?jiān)?李青連,黃洪波,宋永相,王博,謝運(yùn)昌. 環(huán)酯肽類(lèi)抗生素黑莫他丁的高產(chǎn)菌株及其構(gòu)建方法[P]. 廣東：CN104164399A,2014-11-26.
[47]張偲,田新朋,鞠建華,羅明和,尹浩. 一種海洋鏈霉菌及利用其制備Enterocin的方法以及該菌的應(yīng)用[P]. 廣東：CN104087523A,2014-10-08.
[48]鞠建華,丁杰,宋永相. 一種生物堿類(lèi)化合物的制備方法及其在制備抑制鈣離子通道藥物中的應(yīng)用[P]. 廣東：CN103408503A,2013-11-27.
[49]鞠建華,宋永相,黃洪波,張?jiān)? 兩個(gè)環(huán)六肽化合物及其在制備抗菌藥物中的應(yīng)用[P]. 廣東：CN103396476A,2013-11-20.
[50]鞠建華,宋永相,黃洪波,張?jiān)? 一類(lèi)萘醌倍半萜化合物及其在制備抗腫瘤或抗菌藥物中的應(yīng)用[P]. 廣東：CN103396389A,2013-11-20.
[51]鞠建華,宋永相,黃洪波,張?jiān)? 一類(lèi)吩嗪化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN103360329A,2013-10-23.
[52]鞠建華,陳奇,紀(jì)昌濤. 一種海洋咔啉生物堿的生物合成基因簇及其應(yīng)用[P]. 廣東：CN103275976A,2013-09-04.
[53]鞠建華,張?jiān)?黃洪波,劉靜,馬俊英. 一種格瑞克霉素和P-1894B的生物合成基因簇及其應(yīng)用[P]. 廣東：CN103215281A,2013-07-24.
[54]鞠建華,謝運(yùn)昌. 灰綠霉素和綠灰霉素的生物合成基因簇及其應(yīng)用[P]. 廣東：CN102911957A,2013-02-06.
[55]鞠建華,周瀟,黃洪波. 抗生素Tetrathiazomycin A及其制備方法和在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102775427A,2012-11-14.
[56]張長(zhǎng)生,張慶波,李蘇梅,田新朋,張文軍,張海波,李惠賢,張偲,鞠建華. 鏈霉菌和吲哚倍半萜類(lèi)化合物及其制備方法和在制備抗菌抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102757908A,2012-10-31.
[57]鞠建華,周瀟,黃洪波,劉靜. 一類(lèi)環(huán)肽抗生素及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東：CN102746376A,2012-10-24.
[58]張長(zhǎng)生,李慧賢,張慶波,李蘇梅,朱義廣,張光濤,張海波,田新朋,張偲,鞠建華. 廈霉素A和氧廈霉素的生物合成基因簇及其應(yīng)用[P]. 廣東：CN102732534A,2012-10-17.
[59]張長(zhǎng)生,張文軍,田新朋,李蘇梅,張慶波,馬亮,張海波,張偲,鞠建華. 鏈霉菌、抗腫瘤化合物Spiro-Indimycin A-D及其制備方法和應(yīng)用[P]. 廣東：CN102643765A,2012-08-22.
[60]張長(zhǎng)生,張海波,李蘇梅,張改云,張光濤,朱義廣,陳瑞東,肖吉,鞠建華. 友菌素的生物合成基因簇及其應(yīng)用[P]. 廣東：CN102533813A,2012-07-04.
[61]鞠建華,陳子明,黃洪波,宋永相,張長(zhǎng)生. 環(huán)七肽類(lèi)化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102516368A,2012-06-27.
[62]鞠建華,黃洪波,任香梅,宋永相,張長(zhǎng)生. 一類(lèi)角環(huán)素類(lèi)化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102492006A,2012-06-13.
[63]鞠建華,陳子明,黃洪波,宋永相,張長(zhǎng)生. 霉酚酸衍生物Penicacids A、B、C及其在制備免疫抑制藥物中的應(yīng)用[P]. 廣東：CN102391225A,2012-03-28.
[64]鞠建華,朱清華,李軍,馬俊英,田新朋,張長(zhǎng)生. 一種核苷類(lèi)抗生素A201A高產(chǎn)菌株及其構(gòu)建方法[P]. 廣東：CN102373171A,2012-03-14.
[65]張長(zhǎng)生,李蘇梅,田新朋,張文軍,張海波,張光濤,張偲,鞠建華. 抗生素Pseudonocardian A和B及其制備方法和在制備抗菌、抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102351859A,2012-02-15.
[66]張長(zhǎng)生,李蘇梅,牛四文,田新朋,張海波,張光濤,張偲,鞠建華. 抗生素Lobophorin E和F及其制備方法和在制備抗菌、抗腫瘤藥物中的應(yīng)用[P]. 廣東：CN102321133A,2012-01-18.
[67]張偲,張長(zhǎng)生,田新朋,李蘇梅,張文軍,張海波,張光濤,尹浩,鞠建華. 一種假諾卡氏菌及利用其制備Deoxynyboquinone的方法[P]. 廣東：CN102296039A,2011-12-28.
[68]鞠建華,黃洪波,姚月良,田新朋,張長(zhǎng)生. β-咔啉生物堿及其在制備抗瘧疾藥物中的應(yīng)用[P]. 廣東：CN102250089A,2011-11-23.
[69]張長(zhǎng)生,李蘇梅,牛四文,胡濤,張光濤,肖毅,張海波,鞠建華. 六種臺(tái)勾霉素類(lèi)化合物及其制備方法和在制備抗菌藥物中的應(yīng)用[P]. 廣東：CN102219815A,2011-10-19.
[70]鞠建華,周俊勇,黃洪波,馬俊英,王博,汪中文,田新朋,張偲,張長(zhǎng)生. 一種海洋鏈霉菌及利用其制備星形孢菌素和K-252d的方法[P]. 廣東：CN102181387A,2011-09-14.
[71]張長(zhǎng)生,李蘇梅,田新朋,牛四文,鞠建華,張偲. 一種鏈霉菌及利用該菌制備多種抗生素的工藝[P]. 廣東：CN102168044A,2011-08-31.
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發(fā)明授權(quán)：
[1]李青連,許潤(rùn),宋永相,李駿,鞠建華. 一種環(huán)六肽化合物desotamide A4及其在制備抗菌藥物中的應(yīng)用[P]. 廣東省：CN113150077B,2023-06-06.
[2]鞠建華,宋永相,楊佳凡. 一類(lèi)骨架新穎的6/6/6/6/5/5環(huán)生物堿類(lèi)化合物及其在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N114349762B,2023-01-03.
[3]鞠建華,周鎮(zhèn)檳,楊佳凡,宋永相,田新朋. 兩個(gè)大環(huán)內(nèi)酯化合物及其在制備抗菌、抗癌藥物中的應(yīng)用[P]. 廣東�。篊N114437155B,2022-09-20.
[4]宋永相,鞠建華,劉田,李潔,楊佳凡,李曉悅,盧瓊,楊青. 深海放線菌11791在制備防治農(nóng)牧業(yè)鱗翅目害蟲(chóng)藥物中的應(yīng)用[P]. 廣東�。篊N114009451B,2022-09-06.
[5]安法梁,鄭高帆,朱云飛,鞠建華,馬俊英. 利用深海鏈霉菌生產(chǎn)怡萊霉素E的培養(yǎng)基及其制備方法[P]. 上海市：CN112608965B,2022-08-05.
[6]鞠建華,陳姜,桂春,李青連,田新朋. 一種定向生產(chǎn)抗病毒和抗菌活性化合物的基因工程菌株及其應(yīng)用[P]. 廣東�。篊N111269867B,2022-05-10.
[7]鞠建華,邵明偉,孫長(zhǎng)利,李青連,王曉雪. 一種海洋真菌-細(xì)菌共生體及其代謝產(chǎn)物和在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N112694983B,2022-05-06.
[8]楊青,劉田,宋永相,盧瓊,鞠建華. 雙吲哚吡咯類(lèi)化合物的應(yīng)用[P]. 廣東�。篊N113207883B,2022-04-15.
[9]鞠建華,張?zhí)煊?孫長(zhǎng)利,劉志永,馬俊英. 海洋環(huán)肽化合物及其在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東省：CN111303247B,2022-03-22.
[10]鞠建華,李駿,劉志永,馬俊英,張?zhí)煊? 一種怡萊霉素F衍生物及其在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東�。篊N111647050B,2021-11-09.
[11]鞠建華,張善文,桂春,邵明偉,黃洪波. 一種海洋鏈霉菌、衣霉素類(lèi)化合物及其制備方法[P]. 廣東�。篊N108660093B,2021-07-20.
[12]李青連,鞠建華,秦湘靜,劉靜. 一種高產(chǎn)含有L-Val結(jié)構(gòu)單元的化合物的菌株△mfnH[P]. 廣東�。篊N108486028B,2021-06-01.
[13]鞠建華,張善文,田新朋,桂春,秦湘靜,黃洪波. 一種海洋糖多孢菌及其在制備紅霉素衍生物中的應(yīng)用[P]. 廣東�。篊N108485991B,2021-05-18.
[14]馬俊英,鞠建華,黃洪波,張春燕,賈艷璽,李巖. 化合物ilamycin F及其應(yīng)用[P]. 廣東�。篊N110218244B,2021-04-09.
[15]馬俊英,張華,解青,鞠建華. 化合物ilamycin C及其同系物在制備治療三陰乳腺癌藥物中的應(yīng)用[P]. 廣東省：CN109985229B,2021-04-06.
[16]李青連,鞠建華,秦湘靜,劉靜. 一種高產(chǎn)環(huán)肽類(lèi)化合物的菌株[P]. 廣東省：CN108587991B,2021-03-05.
[17]鞠建華,孫長(zhǎng)利,張善文,桂春,張華. 一類(lèi)安莎全碳環(huán)聚酮類(lèi)抗生素及其在制備抗菌藥物或抗腫瘤藥物中的應(yīng)用[P]. 廣東省：CN109810919B,2021-02-09.
[18]鞠建華,潘華奇,田新朋. 一種多功能暹羅芽孢桿菌及其生物活性物質(zhì)的制備和應(yīng)用[P]. 廣東省：CN108060100B,2021-01-29.
[19]宋永相,楊佳凡,賴添財(cái),鞠建華. 深海放線菌生物制劑在制備預(yù)防柑橘潰瘍疾病藥物中的應(yīng)用[P]. 廣東�。篊N111096337B,2020-11-10.
[20]馬俊英,孫長(zhǎng)利,劉志勇,張?zhí)煊?鞠建華. 環(huán)肽類(lèi)抗生素及其制備方法和在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東省：CN109762046B,2020-10-23.
[21]鄧音樂(lè),鞠建華,蒙麗麗,孫長(zhǎng)利,趙朔,孫秀云,陳俐. 一種防治白色念珠菌化合物及其制備方法與應(yīng)用[P]. 廣東省：CN108191693B,2020-06-12.
[22]鞠建華,宋永相,李青連,胡云峰. 一類(lèi)大環(huán)內(nèi)酯化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N106632221B,2020-01-31.
[23]鞠建華,宋永相,李潔,黃洪波. 一種產(chǎn)角環(huán)素化合物的紅灰鏈霉菌[P]. 廣東�。篊N106834160B,2019-12-31.
[24]鞠建華,張?zhí)煊?馬俊英,劉永志. 一種海洋鏈霉菌、及其環(huán)肽化合物在制備抗結(jié)核分枝桿菌藥物中的應(yīng)用[P]. 廣東�。篊N106279370B,2019-09-27.
[25]鞠建華,馬俊英,黃洪波,賈艷璽,張春燕. 環(huán)肽類(lèi)化合物在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N106397544B,2019-09-27.
[26]鞠建華,宋永相,謝運(yùn)昌,秦湘靜. 一種利用深海鏈霉菌SCSIO 5604制備抗生素dihydrotetrodecamycin的方法[P]. 廣東�。篊N105925637B,2019-09-03.
[27]鞠建華,桂春,李青連,程偉鴿. 一種海洋鏈霉菌及其在制備那西肽中的應(yīng)用[P]. 廣東省：CN106119157B,2019-08-13.
[28]鞠建華,馬俊英,黃洪波,張春燕,賈艷璽,李巖. 一種定向生產(chǎn)抗結(jié)核活性和抗腫瘤活性化合物的基因工程菌株及其應(yīng)用[P]. 廣東�。篊N106497827B,2019-08-02.
[29]鞠建華,馬俊英,張?jiān)?李青連,黃洪波,宋永相,王博,謝運(yùn)昌. 環(huán)酯肽類(lèi)抗生素黑莫他丁的高產(chǎn)菌株及其構(gòu)建方法[P]. 廣東省：CN104164399B,2019-06-11.
[30]李文均,劉晴,陳微,高銳,段焰青,侯偉,鞠建華. 一株擬無(wú)枝菌酸菌及利用該菌制備特戊依羅霉素的方法[P]. 廣東�。篊N105886421B,2019-04-02.
[31]鞠建華,李青連,秦湘靜,劉靜. 氨基轉(zhuǎn)移酶和異構(gòu)酶在催化形成L-allo-Ile中的應(yīng)用[P]. 廣東省：CN105154487B,2019-03-05. 國(guó)際授權(quán)專(zhuān)利(日本)PCT/CN2015/097205（日本專(zhuān)利：6565839）
[32]鞠建華,宋永相,許芳. 一類(lèi)環(huán)六肽化合物及其在制備抗良性前列腺增生藥物中的應(yīng)用[P]. 廣東�。篊N105294842B,2018-10-02.
[33]鞠建華,朱清華,黃洪波,宋永相,馬俊英,李青連. 一類(lèi)核苷類(lèi)抗生素及其在制備抗菌藥物中的應(yīng)用[P]. 廣東�。篊N105061537B,2018-02-02.
[34]鞠建華,宋永相,李潔,黃洪波. 一類(lèi)角環(huán)素化合物及其在制備抗腫瘤或抗菌藥物中的應(yīng)用[P]. 廣東�。篊N104744533B,2017-08-25.
[35]鞠建華,張幸,桂春. 一種海洋鏈霉菌及其應(yīng)用[P]. 廣東省：CN104630116B,2017-06-23.
[36]張幸,羅明和,鞠建華. 一種吲哚-3-甲醛類(lèi)化合物的制備方法和應(yīng)用[P]. 廣東�。篊N104402792B,2017-03-22.
[37]張偲,田新朋,鞠建華,羅明和,尹浩. 一種海洋鏈霉菌及利用其制備Enterocin的方法以及該菌的應(yīng)用[P]. 廣東省：CN104087523B,2016-09-14.
[38]鞠建華,宋永相,黃洪波,張?jiān)? 一類(lèi)吩嗪化合物及其在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東�。篊N103360329B,2015-11-18.
[39]張長(zhǎng)生,肖毅,李蘇梅,牛四文,張光濤,張海波,胡濤,鞠建華. 臺(tái)勾霉素的生物合成基因簇及其應(yīng)用[P]. 廣東�。篊N102115757B,2015-10-28.
[40]鞠建華,陳奇,紀(jì)昌濤. 一種海洋咔啉生物堿的生物合成基因簇及其應(yīng)用[P]. 廣東�。篊N103275976B,2015-04-08.
[41]鞠建華,丁杰,宋永相. 一種生物堿類(lèi)化合物的制備方法及其在制備抑制鈣離子通道藥物中的應(yīng)用[P]. 廣東省：CN103408503B,2015-03-11.
[42]鞠建華,宋永相,黃洪波,張?jiān)? 一類(lèi)萘醌倍半萜化合物及其在制備抗腫瘤或抗菌藥物中的應(yīng)用[P]. 廣東�。篊N103396389B,2015-03-04.
[43]鞠建華,宋永相,黃洪波,張?jiān)? 兩個(gè)環(huán)六肽化合物及其在制備抗菌藥物中的應(yīng)用[P]. 廣東省：CN103396476B,2014-12-31.
[44]鞠建華,張?jiān)?黃洪波,劉靜,馬俊英. 一種格瑞克霉素和P-1894B的生物合成基因簇及其應(yīng)用[P]. 廣東�。篊N103215281B,2014-06-25.
[45]鞠建華,謝運(yùn)昌. 灰綠霉素和綠灰霉素的生物合成基因簇及其應(yīng)用[P]. 廣東�。篊N102911957B,2014-06-04.
[46]張長(zhǎng)生,李慧賢,張慶波,李蘇梅,朱義廣,張光濤,張海波,田新朋,張偲,鞠建華. 廈霉素A和氧廈霉素的生物合成基因簇及其應(yīng)用[P]. 廣東�。篊N102732534B,2014-05-14.
[47]張長(zhǎng)生,張慶波,李蘇梅,田新朋,張文軍,張海波,李惠賢,張偲,鞠建華. 鏈霉菌和吲哚倍半萜類(lèi)化合物及其制備方法和在制備抗菌抗腫瘤藥物中的應(yīng)用[P]. 廣東省：CN102757908B,2014-05-14.
[48]張長(zhǎng)生,張海波,李蘇梅,張改云,張光濤,朱義廣,陳瑞東,肖吉,鞠建華. 友菌素的生物合成基因簇及其應(yīng)用[P]. 廣東省：CN102533813B,2014-04-09.
[49]鞠建華,周瀟,黃洪波. 抗生素Tetrathiazomycin A及其制備方法和在制備抗腫瘤藥物中的應(yīng)用[P]. 廣東省：CN102775427B,2014-04-09.
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發(fā)表英文論文：
2020：
[155]Ji, Xiaoqi, Tu, Jiajia, Song, Yongxiang, Zhang, Chunyan, Wang, Liyan, Li, Qinglian; Ju, Jianhua*.A Luciferase-Like Monooxygenase and Flavin Reductase Pair AbmE2/AbmZ Catalyzes Baeyer–Villiger Oxidation in Neoabyssomicin Biosynthesis.ACS Catalysis, 2020, 10(4): 2591-2595.
[154]Shao, Mingwei, Sun, Changli, Liu, Xiaoxiao, Wang, Xiaoxue, Li, Wenli, Wei, Xiaoyi, Li, Qinglian; Ju, Jianhua*.Upregulation of a marine fungal biosynthetic gene cluster by an endobacterial symbiont.Communications Biology, 2020, 3(1): 527., https://doi.org/10.1038/s42003-020-01239-y.
[153]Zhang, Chunyan; Zhang, Huaran; Ju, Jianhua*.On-PKS Baeyer-Villiger-Type O-Atom Insertion Catalyzed by Luciferase-Like Monooxygenase OvmO during Olimycin Biosynthesis.Organic Letters, 2020, 22(5): 1780-1784.
[152]Chen, Jiang; Gui, Chun; Wei, Qiuyu; Liu, Jie; Ye, Li; Tian, Xinpeng; Gu, Yu-Cheng; Li, Qinglian; Ju, Jianhua*.Characterization of Tailoring Methyltransferases Involved in K-41A Biosynthesis: Modulating Methylation to Improve K-41A Anti-infective Activity.Organic Letters, 2020, 22(12): 4627-4632.
[151]Ji, Xiaoqi, Dong, Yuliang, Ling, Chunyao, Zhou, Zhenbin, Li, Qinglian; Ju, Jianhua.Elucidation of the Tailoring Steps in Julichrome Biosynthesis by Marine Gastropod Mollusk-Associated Streptomyces sampsonii SCSIO 054.Organic Letters, 2020, 22(17): 6927-6931.
[150]Li, Qinglian*, Ding, Wenjuan, Tu, Jiajia, Chi, Changbiao, Huang, Hongbo, Ji, Xiaoqi, Yao, Ziwei, Ma, Ming; Ju, Jianhua*.Nonspecific Heme-Binding Cyclase, AbmU, Catalyzes [4 + 2] Cycloaddition during Neoabyssomicin Biosynthesis.ACS Omega, 2020, 5(32): 20548-20557.
[149]Sun, Changli; Liu, Zhiyong; Zhu, Xiangcheng; Fan, Zhiying; Huang, Xuanmei; Wu, Qiaoling; Zheng, Xiaohong; Qin, Xiangjing; Zhang, Tianyu; Zhang, Hua; Ju, Jianhua*; Ma, Junying*.Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 Delta ilaR.Journal of Natural Products, 2020, 83(5): 1646-1657.
[148]Yang, Zhijie; Sun, Changli; Liu, Zhiyong; Liu, Qing; Zhang, Tianyu; Ju, Jianhua*; Ma, Junying*.Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units.Journal of Natural Products, 2020, 83(5): 1666-1673.
[147]Zhou, Zhenbin; Wu, Qiaoling; Xie, Qing; Ling, Chunyao; Zhang, Hua; Sun, Changli; Ju, Jianhua*.New Borrelidins from Onchidium sp. Associated Streptomyces olivaceus SCSIO LO13.Chemistry and Biodiversity, 2020, 17(1): e1900560., doi: 10.1002/cbdv.201900560.
[146]Dong, Yuliang; Ding, Wenjuan; Sun, Changli; Ji, Xiaoqi; Ling, Chunyao; Zhou, Zhenbin; Chen, Zhiyun; Chen, Xuehong*; Ju, Jianhua*.Julichrome Monomers from Marine Gastropod Mollusk-Associated Streptomyces and Stereochemical Revision of Julichromes Q(3.5) and Q(3.3).Chemistry and Biodiversity, 2020, 17(4): e2000057.
[145]Ding, W.; Dong, Yu.; Ju, J.;* Li, Q.* The roles of genes associated with regulation, transportation, and macrocyclization in desotamide biosynthesis in Streptomyces scopuliridis SCSIO ZJ46. Appl. Microbiol. Biotechnol. 2020, 104, 2603-2610.
[144]Yang, Z.; He, J.; Wei, X.; Ju, J.; Ma, J.* Exploration and genome mining of natural products from marine Streptomyces. Appl. Microbiol. Biotechnol. 2020, 104, 67-76.
[143]Song, Yongxiang; Yang, Jiafan; Yu, Jianchen; Li, Jie; Yuan, Jie; Wong, Nai-Kei; Ju, Jianhua*.Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities.Journal of Antibiotics, 2020, 73(8): 542-547.
[142]He, J.; Wei, X.; Yang, Z.; Li, Y.; Ju, J.; Ma, J.* Characterization of regulatory and transporter genes in the biosynthesis of anti-tuberculosis ilamycins and production in a heterologous host. Mar Drugs. 2020, 18(4). pii: E216. doi: 10.3390/md18040216.
[141]Zhou, W.; Liang, H.; Qin, X.; Cao, D.; Zhu, X.; Ju, J.; Shen, B.; Duan, Y.;* Huang, Y.* The isolation of pyrroloformamide congeners and characterization of their biosynthetic gene cluster. J. Nat. Prod. 2020, 83, 202-209.
[140]Liu, L.; Li, S.; Sun, R.; Qin, X.; Ju, J.; Zhang, C.; Duan, Y.;* Huang, Y.* Activation and characterization of bohemamine biosynthetic gene cluster from Streptomyces sp. CB02009. Org Lett. 2020, doi: 10.1021/acs.orglett.0c01224.
[139]Yang Z, He J, Wei X, Ju J, Ma J.* Exploration and genome mining of natural products from marine Streptomyces. Appl Microbiol Biotechnol. 2020, 104, 67-76.
[138] Hou, L.; Liu, Z.; Yu, D.; Li, H.; Ju, J.; Li, W.* Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66. Bioorg. Chem. 2020, doi: 10.1016/j.bioorg.2020.103954.
[137]Kumar, P. S.; Ling, C. Y.; Zhou, Z. B.; Dong, Y. L.; Sun, C. L.; Song, Y. X.; Wong, N. K.; Ju, J. H.*.Chemical Diversity of Metabolites and Antibacterial Potential of Actinomycetes Associated with Marine Invertebrates from Intertidal Regions of Daya Bay and Nansha Islands.Microbiology, 2020, 89(4): 483-492.
[136]Wang, L.; Li, M.; Lin, Y.; Du, S.; Liu, Z.; Ju, J.; Suzuki, H.; Sawada, M.; Umezawa, K.* Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin. J. Antibiot (Tokyo). 2020, doi: 10.1038/s41429-020-0302-9
[135]Yao, Y.; Sun, S.; Cao, M.; Mao, M.; He, J.; Gai, Q.; Qin, Y.; Yao, X.; Lu, H.; Chen, F.; Wang, W.; Luo, M.; Zhang, H.; Huang, H.; Ju, J.; Bian, X.W.,* Wang, Y.* Grincamycin B functions as a potent inhibitor for glioblastoma stem cell via targeting RHOA and PI3K/AKT. ACS Chem. Neurosci. 2020, doi: 10.1021/acschemneuro.0c00206.
[134]Wang, Z.; Li, ZX.; Zhao, WC.; Huang, HB.; Wang, JQ.; Zhang, H.; Lu, JY.; Wang, RN.; Li, W.; Cheng, Z.; Xu, WL.; Zhu, D.; Zhou, LS.; Jiang, W.; Yu, L.; Liu, JY.; Luo, C.; Zhu, H.; Dan, Ye.; Pan, WJ.; Ju, JH.; Dang, YJ.* Identification and characterization of isocitrate dehydrogenase 1(IDH1) as a functional target of marine natural product grincamycin B. Acta. Pharmacol. Sin. 2020, doi: 10.1038/s41401-020-0491-6.
[133]Zhang, Shanwen; Gui, Chun; Shao, Mingwei; Kumar, Pachaiyappan Saravana; Huang, Hongbo*; Ju, Jianhua*.Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077.Natural Product Research, 2020, 34(11): 1499-1504.
2019年：
[132]Gui, Chun; Chen, Jiang; Xie, Qing; Mo, Xuhua; Zhang, Shanwen; Zhang, Hua; Ma, Junying; Li, Qinglian; Gu, Yu-Cheng; Ju, Jianhua*.CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces.COMMUNICATIONS BIOLOGY, 2019, 2: 454.
[131]Liu, Qing; Liu, Zhiyong; Sun, Changli; Shao, Mingwei; Ma, Junying; Wei, Xiaoyi; Zhang, Tianyu*; Li, Wenjun*; Ju, Jianhua*.Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain.Organic Letters, 2019, 21(8): 2634-2638.
[130]Sun, Changli; Yang, Zhijie; Zhang, Chunyan; Liu, Zhiyong; He, Jianqiao; Liu, Qing; Zhang, Tianyu; Ju, Jianhua*; Ma, Junying*.Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster.Organic Letters, 2019, 21(5): 1453-1457.
[129]Xie, Qing; Yang, Zhijie; Huang, Xuanmei; Zhang, Zikang; Li, Jiangbin; Ju, Jianhua*; Zhang, Hua*; Ma, Junying*.Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway.Journal of Hematology & Oncology, 2019, 12(1): 60.. doi:10.1186/s13045-019-0744-3.
[128]Zhang, Shanwen; Xie, Qing; Sun, Changli; Tian, Xin-Peng; Gui, Chun; Qin, Xiangjing; Zhang, Hua*; Ju, Jianhua*.Cytotoxic Kendomycins Containing the Carbacylic Ansa Scaffold from the Marine-Derived Verrucosispora sp. SCSIO 07399.Journal of Natural Products, 2019, 82(12): 3366-3371..
[127]Luo, Minghe; Zang, Ruochen; Wang, Xin; Chen, Ziming; Song, Xiaoxian; Ju, Jianhua*; Huang, Hongbo*.Natural Hydroxamate-Containing Siderophore Acremonpeptides A-D and an Aluminum Complex of Acremonpeptide D from the Marine-Derived Acremonium persicinum SCSIO 115.Journal of Natural Products, 2019, 82(9): 2594-2600.
[126]Zhu, Qinghua; Song, Yongxiang; Huang, Hongbo; Li, Qinglian*; Ju, Jianhua*.Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs.Organic and Biomolecular Chemistry, 2019, 17(15): 3760-3764.
[125]Pan, Huaqi; Tian, Xinpeng; Shao, Mingwei; Xie, Yunchang; Huang, Hongbo; Hu, Jiangchun; Ju, Jianhua*Genome mining and metabolic profiling illuminate the chemistry driving diverse biological activities of Bacillus siamensis SCSIO 05746.Applied Microbiology and Biotechnology, 2019, 103(10): 4153-4165.
[124]Shao, Mingwei; Ma, Juying; Li, Qinglian; Ju, Jianhua*.Identification of the Anti-Infective Aborycin Biosynthetic Gene Cluster from Deep-Sea-Derived Streptomyces sp. SCSIO ZS0098 Enables Production in a Heterologous Host.Marine Drugs, 2019, 17(2): 127.
[123]Liu, Mengchan; Jia, Yanxi; Xie, Yunchang; Zhang, Chunyan; Ma, Junying; Sun, Changli; Ju, Jianhua*.Identification of the Actinomycin D Biosynthetic Pathway from Marine-Derived Streptomyces costaricanus SCSIO ZS0073.Marine Drugs, 2019, 17(4): 240.doi:10.3390/md17040240.
[122]Zhang, Chunyan; Ding, Wenjuan; Qin, Xiangjing; Ju, Jianhua*.Genome Sequencing of Streptomyces olivaceus SCSIO T05 and Activated Production of Lobophorin CR4 via Metabolic Engineering and Genome Mining.Marine Drugs, 2019, 17(10): 593.. doi: 10.3390/md17100593.
[121]Yang, Z.; Wei, X.; He, J.; Ju, J.;* and Ma, J.* Characterization of the noncanonical regulatory and transporter genes in atratumycin biosynthesis and production in a heterologous host. Marine Drugs. 2019, 17(10). pii: E560. doi: 10.3390/md17100560.
[120]Xie, Y.; Li, Q.; Qin, X.; Ju, J. ;* Ma, J.* Enhancement of himastatin bioproduction via inactivation of atypical repressors in Streptomyces hygroscopicus. Metab. Eng. Commun., 2019, 8:e00084; https://doi.org/10.1016/j.mec.2018.e00084.
[119]Huang, Hongbo; Song, Yongxiang; Zang, Ruochen; Wang, Xin; Ju, Jianhua*.Octyl substituted butenolides from marine-derived Streptomyces koyangensis. Natural Product Research.. 2019 Nov 6:1-6. doi: 10.1080/14786419.2019.1686368.
[118]Zhou, W.; Fang, H.; Wu, Q.; Wang, X.; Liu R.; Li, F.; Xiao, J.; Yuan, L.; Zhou, Z.; Ma, J.; Wang, L.; Zhao, W.; You, H.; Ju, J.; Feng, J.;* Chen, C.* Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2. Int. J. Biol. Sci. 2019, 15(8), 1723-1732.
[117] Meng, L.; Sun, C.; Zhang, C.; Song, S.; Sun, X.; Ju, J.; Deng Y.* Efficacy of compounds isolated from Streptomyces olivaceus against the morphogenesis and virulence of Candida albicans. Mar Drugs. 2019, 17(8), pii: E442.
[116]Jiang, L.; Pu, H.; Qin, X.; Liu, J.; Wen, Z.; Huang, Y.; Xiang, J.; Xiang, Y.; Ju, J.; Duan, Y.;* Huang, Y.* Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001. Nat Prod Res. 2019, 1-8. doi: 10.1080/14786419.2019.1611812.
2018年：
[115]Zhang Chunyan; Yang Zhijie; Qin Xiangjing; Ma Junying; Sun Changli; Huang Hongbo; Li Qinglian; Ju Jianhua*.Genome mining for mycemycin: discovery and elucidation of related methylation and chlorination biosynthetic chemistries.Organic Letters, 2018, 20., 7633–7636.
[114]Li Qinglian+*; Ding Wenjuan; Yao Ziwei; Tu Jiajia; Wang Liyan; Huang Hongbo; Li Shengying; Ju jianhua*.AbmV catalyzes tandem ether installation and hydroxylation during neoabyssomicin/abyssomicin biosynthesis.organic letters, 2018, 20(16): 4854-4857.
[113]Qin, Xiangjing; Xie, Yunchang; Huang, Hongbo; Chen, Qi; Ma, Junying; Li, Qinglian; Ju, Jianhua*.Enzymatic Synthesis of GDP-alpha-L-fucofuranose by MtdL and Hyg20.Organic Letters, 2018, 20(4): 1015-1018.
[112]Huang Hongbo; Song Yongxiang; Li Xin; Wang, Xin; Ling Chunyao; Qin Xiangjing; Zhou Zhenbin; Li Qinglian; Wei Xiaoyi; Ju jianhua*.Abyssomicin monomers and dimers from the marine-derived Streptomyces koyangensis SCSIO 5802.Journal of natural products, 2018, 81(8): 1892-1898..
[111]Zhang Chunyan; Sun Changli; Gui Chun; Wang Liyan; Huang Hongbo; Li Qinglian; ju jianhua*.Biosynthetic Baeyer–Villiger chemistry enables access to two anthracene scaffolds from a single gene cluster in deep sea-derived Streptomyces olivaceus SCSIO T05..Journal of natural products, 2018, 81(7): 1570-1577..
[110]Gui, Chun; Yuan, Jie; Mo, Xuhua; Huang, Hongbo; Zhang, Shanwen; Gu, Yu Cheng; Ju, Jianhua*.Cytotoxic Anthracycline Metabolites from a Recombinant Streptomyces.Journal of Natural Products, 2018, 81(5): 1278-1289.
[109]Sun Changli; Zhang Chunyan; Qin Xiangjing; Wei Xiaoyi; Liu Qing; Li Qinglian; Ju jianhua*.Genome mining of Streptomyces olivaceus SCSIO T05: discovery of olimycins A and B and assignment of absolute configurations.Tetrahedron, 2018. 74, 199-203.
[108]Sun, Jianbin; Shao, Junli; Sun, Changli; Song, Yongxiang; Li, Qinglian; Lu, Laichun; Hu, Yunfeng; Gui, Chun; Zhang, Hua*; Ju, Jianhua*.Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.Bioorganic & Medicinal Chemistry, 2018, 26(8): 1488-1494.
[107]Li Yan; Zhang Chunyan; Liu Chengxiong; Ju Jianhua*; Ma Junying.Genome sequencing of Streptomyces atratus SCSIO ZH16 and activation production of nocardamine via metabolic engineering. Frontiers in Micrbiology, 2018, 9: 1269., doi:10.3389/fmicb.2018.01269
[106]Gui, Chun; Liu, Yena; Zhou, Zhenbin; Zhang, Shanwen; Hu, Yunfeng; Gu, Yu Cheng; Huang, Hongbo*; Ju, Jianhua*.Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp SCSIO GJ056.Marine Drugs, 2018, 16(6): 185.; doi:10.3390/md16060185
[105]Tu, J.; Li, S.; Chen, J.; Song, Y.; Fu, S.; Ju, J.; Li, Q.* Characterization and heterologous expression of the gene cluster for neoabyssomincins and abyssomincins biosynthesis from Streptomyces koyangensis SCSIO 5802. Microb. Cell Fact. 2018, 17(1):28. doi: 10.1186/s12934-018-0875-1
[104]Zhang, S.; Gui, C.; Shao, M.; Kumar, S.; Huang, H.;* Ju, J.* Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077. Nat. Prod. Res. 2018, doi:10.1080/14786419.2018.1493736
[103]Guo, Z.; Li, P.; Chen, G.; Li, C.; Cao, Z.; Zhang, Y.; Ren, J.; Xiang, H.; Lin, S.; Ju, J.; Chen, Y.* Design and biosynthesis of dimeric alboflavusins with biaryl linkages via regiospecific C–C bond coupling. J. Am. Chem. Soc., 2018, 140, 18009–18015.
[102]Deng, Y.; Kang, D.; Qiu, L.; Shi, J.; Zhou,W.; Sun, A.; Ju, J.; Zhu, X.; Shen, B.;* Duan, Y.;* Huang, Y.* The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. MedChemComm. 2018, 9, 789-794.
[101]Hou, L.; Huang, H.; Li, H.; Wang, S.; Ju, J.; Li, W.* Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity. Microb. Cell Fact. 2018, 17(1):61 (doi: 10.1186/s12934-018-0908-9).
[100]Lai, Z.; Yu, J.; Ling, H.; Song, Y.; Yuan, J.; Ju, J.; Tao, Y.;* Huang, H.* Grincamycins I - K, cytotoxic angucycline glycosides derived from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. Planta Med. 2018, 84, 201-207.
2017年：
[99]Zhu, Qinghua; Chen, Qi; Song, Yongxiang; Huang, Hongbo; Li, Jun; Ma, Junying; Li, Qinglian; Ju, Jianhua*.Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-L-galactose mutase.Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(19): 4948-4953.
[98]Ma, Junying*; Huang, Hongbo; Xie, Yunchang; Liu, Zhiyong; Zhao, Jin; Zhang, Chunyan; Jia, Yanxi; Zhang, Yun; Zhang, Hua; Zhang, Tianyu; Ju, Jianhua*.Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents.Nature Communications, 2017, 8(1): 391.(doi: 10.1038/s41467-017-00419-5).
[97]Gui, Chun; Mo, Xuhua; Gu, Yu Cheng; Ju, Jianhua*.Elucidating the Sugar Tailoring Steps in the Cytorhodin Biosynthetic Pathway.Organic Letters, 2017, 19(20): 5617-5620.
[96]Gui Chun; Zhang Shanwen; Zhu Xiangcheng; Ding Wenjuan; Huang Hongbo; Gu Yu Cheng; Duan Yanwen; Ju Jianhua*.Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.Journal of Natural Products, 2017, 80(5): 1594-1603.
[95]Luo, Minghe; Cuo, Zhaomeng; Huang, Hongbo; Song, Xianqin; Sun, Aijun; Dang, Yongjun; Lu, Laichun*; Ju, Jianhua*.Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp SCSIO sof101.Journal of Natural Products, 2017, 80(5): 1668-1673.
[94]Xie Yunchang; Ma Junying; Qin Xiangjing; Li Qinglian; Ju Jianhua*.Identification and utilization of two important transporters: SgvT1 and SgvT2, for griseoviridin and viridogrisein biosynthesis in Streptomyces griseoviridis.Microbial Cell Factories, 2017, 16(1): 177. (doi:10.1186/s12934-017-0792-8).
[93]Song, Yongxiang; Li, Qinglian; Qin, Fengxiang; Sun, Changli; Liang, Hao; Wei, Xiaoyi; Wong, Nai Kei; Ye, Li; Zhang, Yun; Shao, Mingwei; Ju, Jianhua*.Neoabyssomicins A-C, polycyclic macrolactones from the deep-sea derived Streptomyces koyangensis SCSIO 5802.Tetrahedron, 2017, 73(36): 5366-5372.
[92]Chen, Erquan; Chen, Qi; Chen, Shaoming; Xu, Bing; Ju, Jianhua*; Wang, Huan*.Mathermycin, a Lantibiotic from the Marine Actinomycete Marinactinospora thermotolerans SCSIO 00652.Applied and Environmental Microbiology, 2017, 83(15): UNSP e00926-17. (doi: 10.1128/AEM.00926-17).
[91] Li, H.; Huang, H.; Hou, L.; Ju, J.; Li, W.* Discovery of antimycin-type depsipeptides from a wbl gene mutant strain of deep sea-derived Streptomyces somaliensis SCSIO ZH66 and their effects on pro-inflammatory cytokine production. Front Microbiol. 2017, 8, 678.
[90]Zhu, X.; Duan, Y.; Cui, Z.; Wang, Z.; Li, Z.; Zhang, Y.; Ju, J.; Huang, H.* Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32. J. Antibiot. 2017, 70, 819-822.
[89]Mo, X.*; Shi, C.; Gui, C.; Zhang, Y.; Ju, J.; Wang, Q.* Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster. Microb. Cell Fact. 2017, 16(1):100.
[88]Lai, Z.; Yu, J.; Ling, H.; Song, Y.; Yuan, J.; Ju, J.; Tao, Y.;* Huang, H.* Grincamycins I - K, cytotoxic angucycline glycosides derived from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. Planta Med. 2017, doi: 10.1055/s-0043-119888.
[87] Li, X.; Xia, Z.; Tang, J.; Wu, J.; Tong, J.; Li, M.; Ju, J.; Chen, H.; Wang, L.* Identification and biological evaluation of secondary metabolites from marine derived fungi-Aspergillus sp. SCSIOW3, cultivated in the presence of epigenetic modifying agents. Molecules, 2017, 22(8), pii: E1302 (doi: 10.3390/molecules22081302).
[86]Wang, Yi Huan; Salam, Nimaichand; Liu, Qing; Yang, Zi Wen; Cao, Li Xiang; Meng, Xiao Lin; Nie, Guo Xing; Ju, Jian Hua*; Li, Wen Jun*.Symbiotic bacteria associated with puffer fish Gastrophysus spadiceus and evaluation of their antimicrobial activities.3 Biotech, 2017, 7(6): 366.
2016年：
[85]Li, Qinglian; Qin, Xiangjing; Liu, Jing; Gui, Chun; Wang, Bo; Li, Jie; Ju, Jianhua*.Deciphering the Biosynthetic Origin of l-allo-Isoleucine..Journal of the American Chemical Society, 2016, 138(1): 408-415. (Highlighted in JACS Spotlights, 2016, 138, 461; Hot off the Press in Natural Products Reports, 2016, 33, 530).
[84]Luo, M.; Tang, G.; Ju, J.; Lu, L.; Huang, H.* A new diketopiperazine derivative from a deep sea-derived Streptomyces sp. SCSIO 04496. Nat. Prod. Res. 2016, 30, 138-143.
[83]Huang, H.; Li, H.; Qiu, Y.; Hou, L.; Ju, J.; Li, W.* A new dioic acid from a wbl gene mutant of deep sea-derived Streptomyces somaliensis SCSIO ZH66. Mar Drugs. 2016, 14(10). pii: E184.
[82]Huang, H.; Hou, L.; Li, H.; Qiu, Y.; Ju, J.; Li, W.* Activation of a plasmid-situated type III PKS gene cluster by deletion of a wbl gene in deepsea-derived Streptomyces somaliensis SCSIO ZH66. Microb. Cell Fact. 2016, 15(1):116.
2015年：
[81]Liu, Jing#; Wang, Bo#; Li, Hongzhi; Xie, Yunchang; Li, Qinglian; Qin, Xiangjing; Zhang, Xing; Ju, Jianhua*.Biosynthesis of the Anti-infective Marformycins Featuring Pre-NRPS Assembly Line N-Formylation and O-Methylation and Post-Assembly Line C-Hydroxylation Chemistries.Organic Letters, 2015, 17(6): 1509-1512. (Hot off the Press in Natural Product Reports).
[80]Gui, Chun#; Li, qinglian#; Mo, xuhua#; Qin, xiangjing; Ma, junying; Ju, jianhua*.Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis.Oganic Letter, 2015, 17(3): 628-631.
[79]Li, Qinglian; Song, Yongxiang; Qin, Xiangjing; Zhang, Xing; Sun, Aijun; Ju, Jianhua*.Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host.Journal of Natural Products, 2015, 78(4): 944-948.
[78]Song, Yongxiang#; Liu, Guangfu#; Li, jie; Huang, hongbo; Zhang, xing; Zhang, Hua*; Ju, jianhua*.Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594.Marine Drugs, 2015, 13(3): 1304-1316.
[77]Medema, M.H.; et al; Xie, Y.; et al; Ju, J.; et al, Glöckner, F.O.* Minimum Information about a Biosynthetic Gene cluster. Nat. Chem. Biol. 2015, 11, 625-631.
[76]Huang, Sheng-Xiong; Yun, Bong-Sik; Ma, Ming; Basu, Hirak S; Church, Dawn R; Ingenhorst, Gudrun; Huang, Yong; Yang, Dong; Lohman, Jeremy R; Tang, Gong-Li; Ju, Jianhua; Liu, Tao; Wilding, George; Shen, Ben*.Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species.Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(27): 8278-8283.
[75]Zhang, Yonghe; Huang, Huiming; Xu, Shanshan; Wang, Bo; Ju, Jianhua; Tan, Huarong; Li, Wenli*.Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology.Microbial Cell Factories, 2015, 14(64): 64.
2014年：
[74]Song, Yongxiang; Li, Qinglian; Liu, Xue; Chen, Yuchan; Zhang, Yun; Sun, Aijun; Zhang, Weimin; Zhang, Jingren; Ju, Jianhua*.Cyclic hexapeptides from the deep South China Sea-derived Streptomyces scopuliridis SCSIO ZJ46 ative against pathogenic gram-positive bacteria.Journal of Natural Products, 2014, 77(8): 1937-1941.
[73]Xie, Yunchang; Li, Qinglian; Song, Yongxiang; Ma, Junying; Ju, Jianhua*.Involvement of SgvP in carbon-sulfur bond formation during griseoviridin biosynthesis.ChemBioChem, 2014, 15(8): 1183-1189. (commented by Faculty of 1000).
[72]Ji, Changtao; Chen, Qi; Li, Qinglian; Huang, Hongbo; Song, Yongxiang; Ma, Junying; Ju, Jianhua*.Chemoenzymatic synthesis of β-carboline derivatives using McbA, a new ATP-dependent amide synthetase.Tetrahedron Letters, 2014, 55(35): 4901-4904.
[71]Mo, Xuhua; Li, Qinglian; Ju, Jianhua*.Naturally occurring tetramic acid products: isolation, structure elucidation and biological activity.RSC Advances, 2014, 4(92): 50566-50593..
[70]Zhou, Xiao#; Huang, Hongbo#; Li, Jie; Song, Yongxiang; Jiang, Rengwang; Liu, Jing; Zhang, Si; Hua, Yan*; Ju, Jianhua*.New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141.Tetrahedron, 2014, 70(42): 7795-7801.
[69]Seo, J.W.; Ma, M.; Kwong, T.; Ju, J.; Lim, S.K.; Jiang, H.; Lohman, J.R.; Yang, C.; Cleveland, J.; Zazopoulos, E.; Farnet, C.M.; Shen, B.* Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. Biochemistry. 2014, 53(49):7854-7865.
[68]Wang, H.; Zhang, H.; Mi, Y.; Ju, J.; Chen, Q.; Zhang, H.* Expression, crystallization and preliminary X-ray analysis of McbB, a multifunctional enzyme involved in β-carboline skeleton biosynthesis. Acta Crystallogr F Struct Biol Commun. 2014, 70(Pt 10), 1402-145.
2013年：
[67]Chen, Qi; Ji, Changtao; Song, Yongxiang; Huang, Hongbo; Ma, Junying; Tian, Xinpeng; Ju, Jianhua*. Discovery of McbB, a novel enzyme catalyzing the β-Carboline skeleton construction in the marinacarboline biosynthetic pathway. Angewandte Chemie International Edition, 2013, 52(38): 9980-9984. (commented by Faculty of 1000).
[66]Zhang, Yun#; Huang, Hongbo#; Chen, Qi; Luo, Minghe; Sun, Aijun; Song, Yongxiang; Ma, Junying; Ju, Jianhua*.Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety. Organic Letters, 2013, 15(13): 3254-3257.
[65] Wang, Bo#; Song, Yongxiang#; Luo, Minghe; Chen, Qi; Ma, Junying; Huang, Hongbo; Ju, Jianhua*. Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation. Organic Letters, 2013, 15(6): 1278-1281.
[64]Song, Yongxiang; Huang, Hongbo; Chen, Yuchan; Ding, Jie; Zhang, Yun; Sun, Aijun; Zhang, Weimin; Ju, Jianhua*.Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. Journal of Natural Products, 2013, 76(12): 2263-2268.
[63]Zhang, Yun; Zhou, Xiao; Huang, Hongbo; Tian, Xinpeng; Song, Yongxiang; Zhang, Si; Ju, Jianhua*. 03219A, a new Δ8,9-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment. Jounary of Antibiotics (Tokyo), 2013, 66(6): 327-331.
[62]Zhang, Huaidong; Chen, Jie; Wang, Hua; Xie, Yunchang; Ju, Jianhua; Yan, Yunjun*; Zhang, Houjin*. Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis. FEBS Letters, 2013, 587(11): 1675-1680.
[61]Ma Ming; Kwong Thomas; Lim Si-Kyu; Ju Jianhua; Lohman Jeremy R; Shen Ben*. Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity. Journal of the American Chemical Society, 2013, 135(7): 2489-2492.
2012年：
[60]Mo, Xuhua; Ma, Junying; Huang, Hongbo; Wang, Bo; Song, Yongxiang; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*.Delta(11,12) double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme. Journal of the American Chemical Society, 2012, 134(6): 2844-2847. (highlighted in Nat. Chem. Biol. 2012, 8, 320).
[59]Zhu, Qinghua; Li, Jun; Ma, Junjing; Luo, Minghe; Wang, Bo; Huang, Hongbo; Tian, Xinpeng; Li, Wenjun; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*. Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from deep sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrob. Antimicrobial Agents and Chemotherapy, 2012, 56(1): 110-114.
[58]Xie, Yunchang; Wang, Bo; Liu, Jing; Zhou, Junchao; Ma, Junying; Huang, Hongbo; Ju, Jianhua*.Identification of the biosynthetic gene cluster and regulatory cascade for the synergistic antibacterial antibiotics griseoviridin and viridogrisein in Streptomyces griseoviridis. ChemBioChem, 2012, 13(18): 2745-2757. (highlighted as an an inside cover).
[57]Ma, Junying; Zuo, Dianguang; Song, Yongxiang; Wang, Bo; Huang, Hongbo; Yao, Yueliang; Li, Wenjun; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*. Characterization of a single gene cluster that is responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans. ChemBioChem, 2012, 13(4): 547-552.
[56]Huang, Hongbo; Yang, Tingting; Ren, Xiangmei; Liu, Jing; Song, Yongxiang; Sun, Aijun; Ma, Junying; Wang, Bo; Zhang, Yun; Huang, Caiguo; Zhang, Changsheng; Ju, Jianhua*.Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32. Journal of Natural Products, 2012, 75(2): 202-208.
[55]Chen, Ziming; Song, Yongxiang; Chen, Yuchan; Huang, Hongbo; Zhang, Weimin; Ju, Jianhua*.Cyclic heptapeptides, cordyheptapeptides C-E, from the marine-derived fungus Acremonium persicinum SCSIO 115 and their cytotoxic activities.Journal of Natural Products, 2012, 75(6): 1215-1219.
[54]Huang, Hongbo#; Wang, Fazuo#; Luo, Minghe#; Chen, Yuchan; Song, Yongxiang; Zhang, Weimin; Zhang, Si; Ju, Jianhua*.Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063.Journal of Natural Products, 2012, 75(7): 1346-1352.
[53]Zhou, Xiao#; Huang, Hongbo#; Chen, Yuchan; Tan, Jiaheng; Song, Yongxiang; Zou, Jianhua; Tian, Xinpeng; Hua, Yan*; Ju, Jianhua*.Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.Journal of Natural Products, 2012, 75(12): 2251-2255.
[52]Chen, Ziming; Zheng, Zhihui; Huang, Hongbo; Song, Yongxiang; Zhang, Xuelian; Ma, Junying; Wang, Bo; Zhang, Changsheng; Ju, Jianhua*.Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07.Bioorganic & Medicinal Chemistry Letters, 2012, 22(9): 3332-3335.
[51]Zhang, W.; Liu, Z.; Li, S.; Yang, T.; Zhang, Q.; Ma, L.; Tian, X.; Zhang, H.; Huang, C.; Zhang, S.; Ju, J; Shen, Y.; Zhang, C.*Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete..Org Lett, 2012, 14(13): 3364-3367.
[50]Zhu, Y.; Fu, P.; Lin, Q.; Zhang, G.; Zhang, H.; Li, S.; Ju, J.; Zhu, W.; Zhang, C.*Identification of caerulomycin A gene cluster implicates a tailoring amidohydrolase..Org Lett, 2012, 14(11): 2666-2669.
[49]Li Huixian#; Zhang Qingbo#; Li Shumei; Zhu Yiguang; Zhang Guangtao; Zhang Haibo; Tian Xinpeng; Zhang Si; Ju Jianhua; Zhang Changsheng*.Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis.Journal of the American Chemical Society, 2012, 134(21): 8996-9005.
2011年：
[48]Ma, Junying; Wang, Zhongwen; Huang, Hongbo; Luo, Minghe; Zuo, Dianguang; Wang, Bo; Sun, Aijun; Cheng, Yiqiang; Zhang, Changsheng; Ju, Jianhua*.Biosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps. Angewandte Chemie International Edition, 2011, 50(34): 7797-7802.(commented by Faculty of 1000).
[47]Mo, Xuhua; Huang, Hongbo; Ma, Junying; Wang, Zhongwen; Wang, Bo; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*.Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway.Organic Letters, 2011, 13(9): 2212-2215.
[46]Huang, Hongbo#; Yao, Yueliang#; He, Zhengxiang; Yang, Tingting; Ma, Junying; Tian, Xinpeng; Li, Yayong; Huang, Caiguo; Chen, Xiaoping; Li, Wenjun; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*.Antimalarial beta-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.Journal of Natural Products, 2011, 74(10): 2122-2127. (highlighted by Global Medical Discovery).
[45]Mo, Xuhua; Wang, Zhongwen; Wang, Bo; Ma, Junying; Huang, Hongbo; Tian, Xinpeng; Zhang, Si; Zhang, Changsheng; Ju, Jianhua*.Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived treptomyces sp. SCSIO1666.Biochemical and Biophysical Research Communications, 2011, 406(3): 341-347.
[44]Chen, Ziming; Huang, Hongbo; Chen, Yuchan; Wang, Zhongwen; Ma, Junying; Wang, Bo; Zhang, Weimin; Zhang, Changsheng; Ju, Jianhua*. New cytochalasins from the marine-derived fungus xylaria sp. SCSIO 156.Helvetica Chimica Acta, 2011, 94(9): 1671-1676.
[43]Huang, Y.; Huang, S-X.; Ju, J.; Tang, G.; Liu, T.; Shen, B.*.Characterization of the InmKLM Genes Unveiling Key Intermediates for beta-Alkylation in Leinamycin Biosynthesis.Organic Letters, 2011, 13(3): 498-501.
[42]Xiao Yi; Li Shumei; Niu Siwen; Ma Liang; Zhang Guangtao; Zhang Haibo; Zhang Gaiyun; Ju Jianhua; Zhang Changsheng*.Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase.Journal of the American Chemical Society, 2011, 133(4): 1092-1105.
[41]Ling, J.*; Zhang, G.; Sun, H.; Fan, Y.; Ju. J.; Zhang, C..Isolation and Characterization of a Novel Pyrene-degrading Bacillus vallismortis strain JY3A.Science of the Total Environment, 2011, 409(10): 1994-2000.
[40]Niu, S.; Hu, T.; Li, S.; Xiao, Y.; Ma, L.; Zhang, G.; Zhang, H.; Yang, X.; Ju, J.; Zhang, C.*.Characterization of a Sugar-O-methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Properties and Reveals Substrate Promiscuity.ChemBioChem, 2011, 12(11): 1740-1748.
[39]Huang, H.; Feng, X.; Xiao, Z.; Liu, L.; Li, H.; Ma, L.; Lu ,Y.; Ju, J.; She, Z.*; Lin, Y.*Azaphilones and p-Terphenyls from the Mangrove Endophytic Fungus Penicillium chermesinum (ZH4-E2) Isolated from the South China Sea.Journal of Natural Products, 2011, 74(5): 997-1002.
[38]Niu, S.; Li, S.; Chen, Y.; Tian, X.; Zhang, H.; Zhang, G.; Zhang, W.; Yang, X.; Zhang, S.; Ju, J.; Zhang, C.*Lobophorins E and F, New Spirotetronate Antibiotics from a South China Sea-derived Streptomyces sp SCSIO 01127.Journal of Antibiotics, 2011, 64(11): 711-716.
[37]Li, S.; Tian, X.; Niu, S.; Zhang, W.; Chen, Y.; Zhang, H.; Yang, X.; Zhang, W.; Li ,W.; Zhang, S.; Ju, J.; Zhang, C.*.Pseudonocardians A-C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp SCSIO 01299.Marine Drugs, 2011, 9(8): 1428-1439.
[36]Huang, H.; Xiao, Z.; Feng, X.; Huang, C.; Zhu, X.; Ju, J.; Li, M.; Lin, Y.; Liu, L.*; She, Zh.*.Cytotoxic Naphtho-γ-pyrones from the Mangrove Endophytic Fungus Aspergillus tubingensis (GX1-5E).Helvetical Chimica Acta, 2011, 94(9): 1732-1740.
Other representative publications：
[35]Schneider-Poetsch Tilman.; Ju Jianhua; Eyler Daniel E; Dang Yongjun; Bhat Shridhar; Merrick William C; Green Rachel; Shen Ben; Liu Jun O*.Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.Nature Chemical Biology, 2010, 6(3): 209-217.
[34]Luo Yinggang; Li Wenli; Ju Jianhua; Yuan Qiuping; Peters Noel R; Hoffmann F Michael; Huang Shengxiong; Bugni Tim S; Rajski Scott; Osada Hiroyuki; Shen Ben*.Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.Journal of the American Chemical Society, 2010, 132(19): 6663-6671.
[33]Zhao, C.; Coughlin, J.; Ju, J.; Zhu, D.; Wendt-Pienkowski, E.; Zhou, X.; Wang, Z.; Shen, B.*; Deng, Z.*Oxazolomycin Biosynthesis in Streptomyces albus JA3453 Featuring an "Acyltransferase-less" Type I Polyketide Synthase That Incorporates Two Distinct Extender Units.Journal of Biological Chemistry, 2010, 285(26): 20097-20108.
[32]Chen, Y.; Wendt-Pienkowski, E.; Ju, J.; Lin, S.; Rajski, S.; Shen, B.*Characterization of FdmV as an Amide Synthetase for Fredericamycin A Biosynthesis in Streptomyces griseus ATCC 43944.Journal of Biological Chemistry., 2010, 285(50): 38853-38860.
[31]Ju, J.; Rajski, S.; Lim, S-K.; Seo, J-W.; Peters, N.; Hoffmann, F.; Shen, B.*Lactimidomycin, Iso-migrastatin and Related Glutarimide-Containing 12-Membered Macrolides Are Extremely Potent Inhibitors of Cell Migration.Journal of the American Chemical Society, 2009, 131(4): 1370-1371.
[30]Ju, J.; Li, W.; Yuan, Q.; Peters, N.; Hoffmann, F.; Rajski, S.; Osada, H.; Shen, B.*.Functional Characterization of ttmM Unveils New Tautomycin Analogs and Insight into Tautomycin Biosynthesis and Activity.Organic Letters, 2009, 11(7): 1639-1642.
[29]Lim, S.; Ju, J.; Zazopoulos, E.; Jiang, H.; Seo, J.; Chen, Y.; Feng, Z.; Rajski, S.; Farnet, C.; Shen, B.*.Iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase.Journal of Biological Chemistry, 2009, 284(43): 29746-29756.
[28]Li, W.; Luo, Y.; Ju, J.; Rajski, S.; Osada, H.; Shen, B.*.Characterization of the Tautomycetin Biosynthetic Gene Cluster from Streptomyces griseochromogenes Provides New Insight into Dialkylmaleic Anhydride Biosynthesis.Journal of Natural Products, 2009, 72(3): 450-459.
[27]Adler, J.T; Cook, M.; Luo, Y.; Pitt, S.; Ju, J.; Li, W.; Shen, B.; Kunnimalaiyaan, M.; Chen, H.*.Tautomycetin and Tautomycin Suppress the Growth of Medullary Thyroid Cancer Cells via Inhibition of Glycogen Synthase Kinase-3 beta.Molecular Cancer Therapeutics, 2009, 8(4): 914-920.
[26]Pinchot, S.; Adler, J.; Luo, Y.; Ju, J.; Li, W.; Shen, B.; Kunnimalaiyaan, M.; Chen, H.*.Tautomycin Suppresses Growth and Neuroendocrine Hormone Markers in Carcinoid Cells through Activation of the Raf-1 Pathway.The American Journal of Surgery, 2009, 197(3): 313-319.
[25]Ju, J.; Rajski, S.; Lim, S-K.; Seo, J-W.; Peters, N.; Hoffmann, F.; Shen, B.*.Evaluation of New Migrastatin and Dorrigocin Congeners Unveils Cell Migration Inhibitors with Dramatically Improved Potency.Bioorganic & Medicinal Chemistry Letters, 2008, 18(22): 5951-5954.
[24]Pinchot, S. N.; Adler, J. T.; Luo, Y.; Ju, J.; Li, W.; Shen, B.; Kunnimalaiyaan, M.; Chen, H*. Tautomycin suppress carcinoid tumor growth and bioactive hormone production through inactivation of the glycogen synthase kinase-3 beta. J. Am. Coll. Surg. 2008, 207, S103-S104.
[23]Song, D.; Coughlin, J.; Ju, J.; Zhou, X.; Shen, B.; Zhao, C.*; Deng, Z.*.Alternative Method for Site-directed Mutagenesis of Complex Polyketide Synthase in Streptomyces albus JA3453.Acta Biochimica et Biophysica Sinica, 2008, 40(4): 319-326.
[22]Zhang, J.; Van Lanen, S.; Ju, J.; Liu, W.; Dorrestein, P.; Li, W.; Kelleher, N.; Shen, B.*.A Phosphopantetheinylating Polyketide Synthase Producing a Linear Polyene to Initiate Enediyne Antitumor Antibiotic Biosynthesis.Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(5): 1460-1465.
[21]Li, W.; Ju, J.; Rajski, S.; Osada, H.; Shen, B.*.Characterization of the Tautomycin Biosynthetic Gene Cluster from Streptomyces Spiroverticillatus Unveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis.Journal of Biological Chemistry, 2008, 283(42): 28607-28617.
[20]Chen, Y.; Luo, Y.; Ju, J.; Wendt-Pienkowski, E.; Rajski, S.; Shen, B.*.Identification of Fredericamycin E from Streptomyces griseus: Insights into Fredericamycin A Biosynthesis Highlighting Carbaspirocycle Formation.Journal of Natural Products, 2008, 71(3): 431-437.
[19]Kennedy, D.; Ju, J.; Shen, B.; Beerman, T.*。Designer Enediynes Generate DNA Breaks, Interstrand Cross-links, or Both, with Concomitant Changes in the Regulation of DNA Damage Responses。Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(45): 17632-17637.
[18]Ju, J.; Seo, J.; Her, Y.; Lim, S-K.; Shen, B.*.New Lactimidomycin Congeners Shed Insight into Lactimidomycin Biosynthesis in Streptomyces amphibiosporus.Organic Letters, 2007, 9(25): 5183-5186.
[17]Guan, C.; Ju, J.; Borlee ,B.; Williamson, L.; Shen, B.; Raffa, K.; Handelsman, J.*.Signal Mimics Derived from a Metagenomic Analysis of the Gypsy Moth Gut Microbiota.Applied and Environment Microbiology, 2007, 73(11): 3669-3676.
[16]Kennedy, D.; Gawron, L.; Ju, J.; Liu, W.; Shen, B.; Beerman, T.*.Single Chemical Modifications of the C-1027 Enediyne Core, a Radiomimetic Antitumor Drug, Affect both Drug Potency and the Role of Ataxia-telangiectasia Mutated in Cellular Responses to DNA Double-strand Breaks.Cancer Research, 2007, 67(2): 773-781.
[15]Ju, J.; Lim, S-K.; Jiang, H.; Seo, J-W.; Her, Y.; Shen, B.*.Thermolysis of Isomigrastatin and its Congeners via [3,3]-sigmatropic Rearrangement: A New Route to the Synthesis of Migrastatin and its Analogues.Organic Letters, 2006, 8(25): 5865-5868.
[14]Li, W.; Ju, J.; Osada, H.; Shen, B.*.Utilization of The Methoxymalonyl-acyl Carrier Protein Biosynthesis Locus for Cloning of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus.Journal of Bacteriology, 2006, 188(11): 4148-4152.
[13]Zhao, C.; Ju, J.; Christenson, S.; Smith, W.; Song, D.; Zhou, X.; Shen, B.*; Deng, Z.*.Utilization of the Methoxymalonyl-acyl Carrier Protein Biosynthesis Locus for Cloning the Oxazolomycin Biosynthetic Gene Cluster from Streptomyces albus JA3453.Journal of Bacteriology, 2006, 188(11): 4142-4147.
[12]Ju, J.; Lim, S.; Jiang, H.; Seo, J.; Shen, B.*.Iso-migrastatin Congeners from Streptomyces platensis and Generation of a Glutarimide Polyketide Library Featuring the Dorrigocin, Lactimidomycin, Migrastatin, and NK30424 Scaffolds.Journal of the American Chemical Society, 2005, 127(34): 11930-11931.
[11]Ju, J.; Lim, S.; Jiang, H.; Shen, B.*.Migrastatin and Dorrigocins are Shunt Metabolites of iso-migrastatin.Journal of the American Chemical Society, 2005, 127(6): 1622-1623.
[10]Van Lanen, S.; Dorrestein, P.; Christenson, S.; Liu, W.; Ju, J.; Kelleher, N.; Shen, B.*.Biosynthesis of the Beta-amino Acid Moiety of the Enediyne Antitumor Antibiotic C-1027 Featuring beta-amino Acyl-S-carrier Protein Intermediates.Journal of the American Chemical Society, 2005, 127(33): 11594-11595.
[9]M.; Van Lanen, S.; Ju, J.; Thorson, J.; Shen, B.*.Antitumor Antibiotics: Bleomycin, Endiynes, and Mitomycin.Chemical Review Galm, U.; Hager, s, 2005, 105(2): 739-758.
[8]Liu, D.; Ju, J.; Zou, Z.; Lin, G.; Yang, J.*.Isolation and Structure Determination of Cypritiibetquinone A and B, two new Phenanthraquinones from Cypripedium Tibeticum.Acta Pharmaceutica Sinica, 2005, 40(3): 255-257.
[7]Ju, J.; Ozanick, S.; Shen, B.; Thomas, M.*Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the Viomycin Biosynthetic Pathway of Streptomyces sp strain ATCC11861.ChemBioChem, 2004, 5(9): 1281-1285.
[6]Ju, J.; Zhou, L.; Lin, G.; Liu, D.; Wang, L-W.; Yang, J-S.*.Studies on Constituents of Triterpene acids from Eriobotrya japonica and Their Anti-inflammatory and Antitussive Effects.Chinese Pharmaceutical Journal, 2003, 38(10): 752-757.
[5]Ju, J.*; Liu, D.; Lin, G.; Xu, X.; Han, B.; Yang, J.*; Tu, G.; Ma, L..Beesiosides A-F, Six New Cycloartane Triterpene Glycosides from Beesia calthaefolia.Journal of Natural Products, 2002, 65(1): 42-47.
[4]Liu, D.; Ju, J.; Lin, G.; Xu, X.; Yang, J.*; Tu, G. New C-glycosylflavones from Tetrastigma Hemsleyanum (Vitaceae).Acta Botanica Sinica, 2002, 44(2): 227-229.
[3]Ju, J.*; Liu, D.; Lin, G.; Zhang, Y.; Yang, J.*; Lu, Y.; Gong, N; Zhene, Q..Beesiosides G, H, and J-N, Seven New Cycloartane Triterpene Glycosides from Beesia calthifolia.Journal of Natural Products, 2002, 65(2): 147-152.
[2]Ju, J.; Liu, D.; Lin, G.; Xu, X.; Yang, J.*; Tu, G.; Ma, L..New Triterpenic Glucoside from Beesia calthaefolia (Maxim.) Ulbr. native to China.Acta Botanica Sinica, 2001, 43(9): 983-987.
[1]Ju, J.; Yang, J.*; Li, J.; Xiao, P.Cypripediquinone A, a New Phenanthraquinone from Cypripedium macranthum (Orchidaceae).Chinese Chemical Letters, 2000, 11(1): 37-38.
發(fā)表中文期刊論文：
[1]宋永相,李曉悅,鞠建華. 深海放線菌Streptomyces koyangensis SCSIO 5802中次級(jí)代謝產(chǎn)物neoabyssomicin H的分離鑒定[J]. 熱帶海洋學(xué)報(bào),2023,42(03):169-173.
[2]吳巧靈,孫長(zhǎng)利,周鎮(zhèn)檳,喬伊君,苗宗余,蔡磊,鞠建華. 石磺來(lái)源海洋鏈霉菌Streptomyces ardesiacus SCSIO LO23中g(shù)ermicidin類(lèi)化合物的分離鑒定及其生物合成分析[J]. 微生物學(xué)報(bào),2022,62(07):2594-2609.
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[4]梁智鋮,李駿,凌春耀,許潤(rùn),譚彬,黃洪波,鞠建華,李青連. 海洋鏈霉菌Streptomyces parvus SCSIO Mla-L010中大環(huán)內(nèi)酰胺類(lèi)抗生素vicenistatin的糖基定向改造[J]. 中國(guó)海洋藥物,2021,40(06):1-12.
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[6]李艷青,凌春耀,易湘茜,高程海,鞠建華,馬俊英. 海鞘來(lái)源放線菌Streptomyces pratensis SCSIO LCY05中skyllamycins的發(fā)現(xiàn)及其生物合成分析[J]. 中國(guó)海洋藥物,2021,40(03):1-14.
[7]于東琪,侯路寬,李花月,鞠建華,李文利. 深海鏈霉菌Streptomyces somaliensis SCSIO ZH66 ptm生物合成基因簇中orf7功能的探究[J]. 中國(guó)海洋藥物,2021,40(03):15-21.
[8]周曉雪,楊佳凡,李明哲,宋永相,鞠建華,李曉帆,王立巖. 珊瑚來(lái)源真菌Parengyodontium album SCSIO SX7W11中聚酮化合物的發(fā)現(xiàn)及其生物合成途徑分析[J]. 微生物學(xué)報(bào),2021,61(11):3631-3641.
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[10]凌春耀,黃洪波,高程海,秦湘靜,鞠建華,易湘茜. 海鞘來(lái)源放線菌Streptomyces pratensis SCSIO LCY05中anthracimycin類(lèi)化合物及其抗菌活性研究[J]. 中國(guó)海洋藥物,2020,39(03):7-14.
[11]涂佳佳,鞠建華,付少彬,李青連. 海洋放線菌Streptomyces koyangensis SCSIO 5802中多烯大環(huán)內(nèi)酯類(lèi)抗生素candicidin生物合成基因簇的分析鑒定[J]. 遵義醫(yī)學(xué)院學(xué)報(bào),2019,42(01):35-44.
[12]徐明遠(yuǎn),肖菲,李花月,鞠建華,李文利. 色氨酸分解代謝途徑阻斷對(duì)深海鏈霉菌ZH66次級(jí)代謝及生長(zhǎng)的影響[J]. 中國(guó)海洋藥物,2018,37(06):8-14.
[13]張善文,桂春,秦湘靜,田新朋,鞠建華. 海洋放線菌S. erythraea SCSIO 07745中紅霉素衍生物及其生物合成基因簇的分析[J]. 中國(guó)海洋藥物,2018,37(05):1-12.
[14]紀(jì)曉奇,李青連,鞠建華. 融合表達(dá)氨基轉(zhuǎn)移酶DsaD和異構(gòu)酶DsaE合成L-別異亮氨酸[J]. 微生物學(xué)通報(bào),2018,45(09):2006-2013.
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[19]陳奇,秦湘靜,李青連,鞠建華. Marinacarbolines甲基化基因mcbD的篩選及其功能[J]. 微生物學(xué)報(bào),2017,57(07):1095-1105.
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[21]鞠建華,周雪峰,朱偉明,漆淑華,徐剛明. 863課題“深海微生物活性物質(zhì)的挖掘及其利用技術(shù)”2013年度進(jìn)展[J]. 科技資訊,2016,14(09):171-172.
[22]李宏志,劉靜,李青連,鞠建華. 抗感染海洋天然產(chǎn)物marformycin生物合成基因簇中調(diào)控基因及轉(zhuǎn)運(yùn)基因的功能研究[J]. 中國(guó)海洋藥物,2016,35(01):10-18.
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[26]羅明和,黃洪波,盧來(lái)春,鞠建華. 海洋真菌Eurotium amstelodami SCSIO 151二酮哌嗪吲哚生物堿類(lèi)次生代謝產(chǎn)物的研究[J]. 天然產(chǎn)物研究與開(kāi)發(fā),2015,27(01):50-54+147.
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[28]謝運(yùn)昌,鞠建華*. 綠灰霉素生物合成途徑中3-羥基吡啶甲酸起始結(jié)構(gòu)單元的活化特異性[J]. 微生物學(xué)報(bào),2013,53(11):1179-1188.
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[30]張?jiān)?周瀟,宋永相,陳蕓蕓,黃洪波,李潔,華燕,鞠建華*. 南海深海鏈霉菌Streptomyces albiflaviniger SCSIO ZJ28中Elaiophylin的分離鑒定[J]. 天然產(chǎn)物研究與開(kāi)發(fā),2013,25(02):185-189.
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[32]左佃光,馬俊英,王博,黃洪波,劉靜,張?jiān)?鞠建華*. 非核糖體肽類(lèi)化合物的組合生物合成策略研究進(jìn)展[J]. 中國(guó)抗生素雜志,2012,37(03):168-175.
[33]李軍,朱清華,張?jiān)?馬俊英,田新朋,李文均,張長(zhǎng)生,鞠建華*. 深海放線菌Marinactinospora thermotolerans SCSIO 00652遺傳操作系統(tǒng)的建立[J]. 中國(guó)抗生素雜志,2012,37(02):105-111.
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[35]陳子明,汪中文,黃洪波,陳玉嬋,章衛(wèi)民,張長(zhǎng)生,鞠建華*. 海洋真菌Xylaria sp.SOF11中細(xì)胞松弛素類(lèi)化合物的研究[J]. 天然產(chǎn)物研究與開(kāi)發(fā),2011,23(05):801-804.
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[63]林耕; 許旭東; 劉東; 鞠建華; 楊峻山.憽木皂苷C的結(jié)構(gòu)研究.中國(guó)藥學(xué)雜志, 2000, 35(5): 33-35.
[64]劉東; 鞠建華; 許旭東; 林耕; 楊峻山.三葉青化學(xué)成分的研究.中國(guó)藥學(xué)雜志, 2000, 35(5): 31-33.
[65]鞠建華,楊峻山. 鐵破鑼化學(xué)成分的研究Ⅰ[J]. 中國(guó)藥學(xué)雜志,1999, 34(9): 585-586.
[66]鞠建華,余競(jìng)光. 假鷹爪種子化學(xué)成分的研究[J]. 中國(guó)中藥雜志,1999,(07):35-38+63.
[67]鞠建華; 楊峻山.升麻族植物三萜皂甙的研究進(jìn)展.中國(guó)中藥雜志, 1999, 24(9): 517-521.
發(fā)表會(huì)議論文：
[1]鞠建華. 海洋微生物抗感染藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成[A].第十一屆全國(guó)化學(xué)生物學(xué)學(xué)術(shù)會(huì)議論文摘要（第一卷）[C].,2019:203.
[2]鞠建華. 海洋微生物抗感染藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成[A]. 中國(guó)化學(xué)會(huì)第十二屆全國(guó)天然有機(jī)化學(xué)學(xué)術(shù)會(huì)議論文摘要集[C].2018:136.
[3]鞠建華. Discovery and engineered production of enhanced anti-tuberculosis ilamycins[A].第三屆中意活性天然產(chǎn)物研討會(huì)暨第一屆國(guó)際藥物化學(xué)論壇論文集[C].2017:47.
[4]鞠建華. 海洋微生物藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成[A].第十屆全國(guó)化學(xué)生物學(xué)學(xué)術(shù)會(huì)議報(bào)告摘要集[C].2017:129.
[5]鞠建華.Discovery and Biosynthesis of Anti-infective Cyclic Pepetides from Marine Actinomycetes.海洋藥物與天然藥物研究國(guó)際學(xué)術(shù)研討會(huì), China,Guangxi Zhuang Autonomous Region,Nanning, 2015-11-23 to 2015-11-25.
[6]鞠建華.Discovery and Biosynthesis of Bioactive Natural Products from Marine Actinomycetes.2015' Yangling International Agri-Science Forum, 2015-11-05 to 2015-11-07.
[7]鞠建華.Deciphering the Biosynthetic Origin of L-allo-isoleucine.International Symposium on Biosystem and Biodesign Engineering 2015: Microbial Signal Regulation Network and Cell Factories, ISBBE 2015 , China,Shanghai, 2015-11-01 to 2015-11-03.
[8]鞠建華.海洋放線菌藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成.2015年中國(guó)微生物學(xué)會(huì)學(xué)術(shù)年會(huì), 中國(guó),湖北省,宜昌市, 2015-10-23至2015-10-25.
[9]鞠建華.Discovery and Biosynthesis of Anti-infective and Anti-tumor Natural Products from Marine-derived Actinomycetes.2015 International Conference on Greeen Pharmaceuticals, 2015-10-17 to 2015-10-18.
[10]鞠建華.Discovery and Biosynthesis of Anti-infective and Anti-tumor Natural Products from Marine Actinomycetes.Sino-German Symposium on Natural Product Sciences, China,Hubei,Wuhan, 2015-10-01 to 2015-10-06.
[11]鞠建華.海洋微生物藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成.中國(guó)化學(xué)會(huì)第九屆全國(guó)化學(xué)生物學(xué)學(xué)術(shù)會(huì)議, 中國(guó),天津市, 2015-08-28至2015-08-31.
[12]鞠建華. 海洋放線菌抗感染、抗腫瘤藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成[A].中國(guó)化學(xué)會(huì)第十屆全國(guó)天然有機(jī)化學(xué)學(xué)術(shù)會(huì)議論文集——第三分會(huì)場(chǎng)：天然產(chǎn)物合成生物學(xué)、化學(xué)生物學(xué)及新技術(shù)[C].2014:15.
[13]馬俊英,周瀟,周俊超,張春燕,程偉鴿,陳奇,鞠建華. 抗感染環(huán)肽化合物Ilamycins生物合成基因簇的克隆及其后修飾基因的功能研究[A].中國(guó)化學(xué)會(huì)第十屆全國(guó)天然有機(jī)化學(xué)學(xué)術(shù)會(huì)議論文集——第三分會(huì)場(chǎng)：天然產(chǎn)物合成生物學(xué)、化學(xué)生物學(xué)及新技術(shù)[C].,2014:66.
[14]陳奇,紀(jì)昌濤,張?jiān)?宋永相,黃洪波,馬俊英,王博,李青蓮,鞠建華. 深海放線菌Actinoalloteichus sp.SCSIO ZJ63中β-咔啉生物堿類(lèi)化合物的挖掘[A].2014年中國(guó)藥學(xué)大會(huì)暨第十四屆中國(guó)藥師周論文集[C].2014:167.
[15]桂春,黃洪波,宋永相,張幸,鞠建華. 深海來(lái)源放線菌Marinactinospora sp.LMJ08次級(jí)代謝產(chǎn)物的研究[A]. 2014年中國(guó)藥學(xué)大會(huì)暨第十四屆中國(guó)藥師周論文集[C].,2014:556.
[16]桂春; 李青連; 莫旭華; 謝運(yùn)昌; 馬俊英; 鞠建華.一類(lèi)新型Dieckmann環(huán)化酶功能的研究.第二屆中國(guó)放線菌生物學(xué)與產(chǎn)業(yè)化研討會(huì), 2014-12-07.
[17]陳奇; 紀(jì)昌濤; 張?jiān)? 宋永相; 黃洪波; 馬俊英; 王博; 李青蓮; 鞠建華.深海放線菌Actinoalloteichus sp.SCSIO ZJ63中β-咔啉生物堿類(lèi)化合物的挖掘.2014年中國(guó)藥學(xué)大會(huì)暨第十四屆中國(guó)藥師周論文集.
[18]張春燕,馬俊英,鞠建華. 抗感染抗生素Ilamycins生物合成基因簇的克隆及其功能研究[A].2014年中國(guó)藥學(xué)大會(huì)暨第十四屆中國(guó)藥師周論文集[C].2014:2858-2859.
[19]劉晴,張永光,桂春,宋永相,黃洪波,李文均,鞠建華. 耐堿放線菌Nocardiopsis sp.EGI80425中安莎菌素的分離及鹵素喂養(yǎng)實(shí)驗(yàn)的探索[A].2014年中國(guó)藥學(xué)大會(huì)暨第十四屆中國(guó)藥師周論文集[C].2014:3294.
[20]程偉鴿,李青連,鞠建華. 海洋來(lái)源鏈霉菌屬SCSIO 3406中phenaziterpene的生物合成研究[A].2014年中國(guó)藥學(xué)大會(huì)暨第十四屆中國(guó)藥師周論文集[C].2014:220.
[21]賈艷璽,張龍霞,張善文,李潔,閆素君,鞠建華,宋永相. 海洋放線菌SCSIO13263抗耐藥性細(xì)菌活性次級(jí)代謝產(chǎn)物的研究[A].2014年中國(guó)藥學(xué)大會(huì)暨第十四屆中國(guó)藥師周論文集[C].2014:783.
[22]李宏志,馬俊英,李青連,鞠建華. Himstatin生物合成基因簇中肽單加氧酶HmtM的功能研究[A].2014年中國(guó)藥學(xué)大會(huì)暨第十四屆中國(guó)藥師周論文集[C].2014:925.
[23]鞠建華.Discovery and Biosynthesis of Anti-infective and Anti-tumor Natural Products from Marine Actinomycetes.第二屆中國(guó)放線菌生物學(xué)與產(chǎn)業(yè)化研討會(huì), China,Guangdong,Guangzhou, 2014-12-07 to 2014-12-09.
[24]鞠建華.Anti-infective and Anti-tumor Natural Products Discovery and Biosynthesis from Marine Actinomycetes.3rd Annual conference of the International Chemical Biology Society, United States, 2014-11-17 to 2014-11-19.
[25]陳奇,馬俊英,朱清華,紀(jì)昌濤,鞠建華. 深海放線菌Marinactinospora thermotolerans SCSIO 00652抗感染、抗腫瘤藥物先導(dǎo)化合物的發(fā)現(xiàn)及其生物合成[A].第八屆全國(guó)化學(xué)生物學(xué)學(xué)術(shù)會(huì)議論文摘要集[C].2013:173.
[26] 鞠建華.Anti-infective and Anti-tumor Natural Products Discovery and Biosynthesis from Marine Actinomycetes and Fungi.Sino-Swiss Stepping Stone Symposium on Natural Products and Drug Discovery, China,Shanghai, 2013-10-23 to 2013-10-26.
[27]鞠建華.海洋微生物特征代謝產(chǎn)物的生物合成.第十一屆海洋藥物學(xué)術(shù)年會(huì), 中國(guó),海南省,�？谑�, 2013-10-18至2013-10-20
[28]鞠建華,馬俊英,黃洪波,宋永相,王博,朱清華,莫旭華,周瀟. 海洋微生物活性次級(jí)代謝產(chǎn)物的發(fā)現(xiàn)及其生物合成[A].第四屆全國(guó)微生物資源學(xué)術(shù)暨國(guó)家微生物資源平臺(tái)運(yùn)行服務(wù)研討會(huì)論文集[C].2012:18-19.
[29]鞠建華.Discovery and Biosynthesis of Bioactive Natural Products from the Deep South China Sea-derived Marinactinospora thermotolerans SCSIO 00652.IOCD International Conference on Functional Molecules in Nature, China,Jiangsu,Nanjing, 2012-09-22 to 2012-09-24.
[30]黃洪波,陳子明,姚月良,羅明和,任香梅,周俊勇,馬俊英,王博,宋永相,張長(zhǎng)生,鞠建華. 海洋微生物活性先導(dǎo)化合物的發(fā)現(xiàn)及其生物活性研究[A].2011年中國(guó)藥學(xué)大會(huì)暨第11屆中國(guó)藥師周論文集[C].2011:111-119.
[31]張改云,李蘇梅,牛四文,胡濤,肖毅,鞠建華,張長(zhǎng)生. 二糖核苷類(lèi)抗生素友菌素的生物合成研究[A]. 中國(guó)化學(xué)會(huì)第八屆天然有機(jī)化學(xué)學(xué)術(shù)研討會(huì)論文集[C].2010:104.
[32]鞠建華. 深海放線菌新屬M(fèi)arinactinospora thermotolerans中抗菌、抗腫瘤活性先導(dǎo)化合物的發(fā)現(xiàn)、生物合成和工程改造[A].中國(guó)化學(xué)會(huì)第八屆天然有機(jī)化學(xué)學(xué)術(shù)研討會(huì)論文集[C].,2010:41.
[33]莫旭華,汪中文,姚月良,馬俊英,王博,黃洪波,張長(zhǎng)生,鞠建華. 替達(dá)霉素生物合成基因簇的克隆及其生物合成機(jī)制研究[A].2010年第四屆全國(guó)微生物遺傳學(xué)學(xué)術(shù)研討會(huì)論文摘要集[C].,2010:91.
[34]肖毅,李蘇梅,牛四文,馬亮,胡濤,張改云,張光濤,鞠建華,張長(zhǎng)生. 新型抗菌劑臺(tái)勾霉素的生物合成研究[A]..2010年第四屆全國(guó)微生物遺傳學(xué)學(xué)術(shù)研討會(huì)論文摘要集[C].2010:30.
[35]鞠建華,張長(zhǎng)生. 海洋微生物活性先導(dǎo)化合物的發(fā)現(xiàn)及其組合生物合成[A].第七屆全國(guó)天然有機(jī)化學(xué)學(xué)術(shù)研討會(huì)論文集[C].2008:154-155.
[36]鞠建華,王平,李志忠,王永江,張登榮,趙繼成,葛榜軍,朱博勤,黨福星,楊日紅. “十五”期間國(guó)土資源遙感科技進(jìn)展[A].“十五”重要地質(zhì)科技成果暨重大找礦成果交流會(huì)材料一——“十五”地質(zhì)行業(yè)各部門(mén)地質(zhì)與找礦成果綜述[C].,2006:15-23.
[37]鞠建華,李志忠. 前言[A].全國(guó)國(guó)土資源與環(huán)境遙感技術(shù)應(yīng)用交流會(huì)論文文集[C].2004:3-4.
[38]鞠建華,宋宏儒,周萍.我國(guó)西南地區(qū)石漠化現(xiàn)狀遙感調(diào)查[A].全國(guó)國(guó)土資源與環(huán)境遙感技術(shù)應(yīng)用交流會(huì)論文文集[C],2004:21-24.
[39]馬立斌,涂光忠,安冬各,鞠建華,劉東,林耕,許旭東,楊峻山. 中國(guó)特有藥用植物鐵破鑼中新六糖皂甙結(jié)構(gòu)的確定[A].第十一屆全國(guó)波譜學(xué)學(xué)術(shù)會(huì)議論文摘要集[C].2000:77-78.
[40]許旭東,劉東,鞠建華,林耕,楊峻山. 安徽楤木中三個(gè)新的常春藤三萜皂甙[A]. 國(guó)際傳統(tǒng)醫(yī)藥大會(huì)論文摘要匯編[C].2000:425.
[41]許旭東,劉東,鞠建華,林耕,楊峻山. 安徽楤木中三個(gè)新的齊墩果酸型三萜皂甙[A]. .國(guó)際傳統(tǒng)醫(yī)藥大會(huì)論文摘要匯編[C].2000:425-426.
鞠建華，男，1972年生，博士，現(xiàn)任山東大學(xué)藥學(xué)院院長(zhǎng)，教授，博士生導(dǎo)師。1995年畢業(yè)于山東醫(yī)科大學(xué)藥學(xué)系，獲理學(xué)學(xué)士學(xué)位；2000年畢業(yè)于中國(guó)協(xié)和醫(yī)科大學(xué)（現(xiàn)北京協(xié)和醫(yī)學(xué)院），獲理學(xué)博士學(xué)位。先后在中國(guó)醫(yī)學(xué)科學(xué)院（2000.08-2003.02）、美國(guó)威斯康星-麥迪遜大學(xué)藥學(xué)院（2003.03-2008.02）和中國(guó)科學(xué)院南海海洋研究所（2008.03-2021）工作。主要從事(海洋)微生物活性次級(jí)代謝產(chǎn)物的發(fā)現(xiàn)、生物合成和抗感染、抗腫瘤創(chuàng)新藥物研發(fā)工作，從(海洋)微生物中發(fā)現(xiàn)了具有抗感染、抗腫瘤等活性天然產(chǎn)物1000余個(gè)，開(kāi)發(fā)了海洋微生物的組合生物合成和異源表達(dá)技術(shù)，闡明了20余種特征活性代謝產(chǎn)物的生物合成機(jī)制，揭示了咔啉堿合成酶、Dieckmann縮合酶、Diels-Alder環(huán)化酶、別異亮氨酸異構(gòu)酶、細(xì)胞色素P450氧化酶、L-半乳糖變構(gòu)酶等26種新穎生物合成酶的催化功能，篩選出3個(gè)自主產(chǎn)權(quán)的抗結(jié)核桿菌感染、抗膠質(zhì)瘤和抗白血病候選海洋藥物，其中1個(gè)在系統(tǒng)臨床前研究。主持國(guó)家重點(diǎn)研發(fā)計(jì)劃、國(guó)家自然科學(xué)基金重點(diǎn)、NSFC-廣東聯(lián)合基金重點(diǎn)項(xiàng)目等20余項(xiàng)。獲得第五屆施維雅青年藥物化學(xué)獎(jiǎng)、第七屆藥明康德生命化學(xué)研究獎(jiǎng)。現(xiàn)任中國(guó)藥學(xué)會(huì)海洋藥物專(zhuān)業(yè)委員會(huì)副主任委員；中國(guó)微生物學(xué)會(huì)海洋微生物專(zhuān)業(yè)委員會(huì)副主任委員；國(guó)際學(xué)術(shù)刊物J. Nat. Prod.、Mar. Drugs顧問(wèn)編委，中國(guó)海洋藥物編委。2008年入選中科院人才學(xué)者，2014年獲得國(guó)家杰出青年科學(xué)基金、同年入選科技部“創(chuàng)新人才推進(jìn)計(jì)劃”中青年科技創(chuàng)新領(lǐng)軍人才，2016年入選國(guó)家特支計(jì)劃科技創(chuàng)新領(lǐng)軍人才和廣東特支計(jì)劃“南粵百杰”杰出人才, 2020年入選國(guó)務(wù)院特殊津貼專(zhuān)家。在Nat. Chem. Biol.,Nature Commun.,PNAS、J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Org. lett.,J. Nat. Prod.等學(xué)術(shù)刊物發(fā)表論文208篇，論文被SCI引用超過(guò)5000次，獲授權(quán)專(zhuān)利24項(xiàng)。 
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